HOMEOSTATIC PROLIFERATION: FROM HEALTH TO PATHOLOGY

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Abstract

In this review, we summarized contemporary knowledge about homeostatic maintenance and homeostatic proliferation of effector and regulatory T-cells, which are two main branches of the immune system that provide immune equilibrium and tolerance. Homeostatic proliferation is a normal physiological process caused by lymphopenia to maintain a constant level of T-cells in the periphery, but sometimes it may acquire pathological traits. Here we will discuss mechanisms of positive and negative influences on immunity during homeostatic proliferation, which may arise in different conditions. We supposed here, that the main of these conditions are decreased thymic output and deep lymphopenia, which lead to fast expansion of T-effectors with high-affinity T-cell receptor to self-antigens, and to inhibitory impacts on T-regulatory lymphocytes by increased levels of homeostatic cytokines that eventually raises a risk of development different autoimmune processes.

About the authors

D. V. Shevyrev

Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology

Author for correspondence.
Email: dr.daniil25@mail.ru

PhD student, laboratory of clinical immunopathology

630099 Novosibirsk, Yadrintsevskaya st.14

Russian Federation

V. P. Tereshchenko

Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology

Email: fake@neicon.ru

PhD student, laboratory of molecular immunology

Novosibirsk

Russian Federation

V. A. Kozlov

Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology

Email: fake@neicon.ru

Full Member of the Russian Academy of Sciences, doctor of medical sciences, professor

Novosibirsk Russian Federation

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