HUMORAL AND CELLULAR IMMUNITY IN HUMANS VACCINATED AND REVACCINATED AGAINST MENINGOCOCCAL INFECTION


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Abstract

T-lymphocytes of vaccinated peopleare involved in the post-vaccination immune response to the polysaccharide vaccine against the A, C, Y and W serogroups of N. meningitidis even if the vaccine is not a glycoprotein conjugate, but the functional activity of T-lymphocytes producing IFNγ and IL-4 is diff erent in the primary and secondary response to the vaccine.If in revaccinated people the humoral immune response to the A-polysaccharide of N. meningitidis is poorly developed, there is the lack of activity of T-lymphocytes that produce IFNγ in their blood and the change in the balance between the activity of Th1 and Th2 is more similar to the dynamics of the primary vaccinated people, rather than successfully revaccinated.

About the authors

M. S. Blyakher

G. N. Gabrichevsky Research Institute of epidemiology and microbiology
Moscow

Email: fake@neicon.ru

DSci (Medicine), Professor, Head of the Laboratory for the Study of Cellular and Molecular Bases of Immunity,

Moscow

Russian Federation

I. M. Fedorova

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

PhD (Medicine), Leading Researcher, Department of Immunology,

Moscow

Russian Federation

S. I. Koteleva

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

PhD (Medicine), Leading Researcher, Department of Immunology,

Moscow

Russian Federation

Z. K. Ramazanova

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

PhD (Medicine), Senior Researcher, Department of Immunology,

Moscow

Russian Federation

S. Yu. Kombarova

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

D. Sci (Biology), Head of Laboratory of Coccoid Infections,

Moscow

Russian Federation

I. G. Martynenko

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

Researcher, Laboratory of Coccoid Infections,

Moscow

Russian Federation

E. A. Tulskaya

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Author for correspondence.
Email: etul@mail.ru

PhD (Biology), Senior Researcher, Department of Immunology,

Moscow

Russian Federation

References

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  2. Keiser P. B., Broderick M. Meningococcal polysaccharide vaccine failure in a patient with C7 deficiency and a decreased anti-capsular antibody response. // Hum. Vaccin. Immunother.2012; 8 (5): 582–586.
  3. Milagres L. G., Costa P. R., Santos B. A., Silva G. P., Cruz A. C., Perejra-Manfro W. F., Ferreira B., Barreto D. M. CD4+ T-cell activation impairs serogroup C Neisseria meningitis vaccine response in HIV-infected children.// AIDS. 2013; 27 (17): 2697–2705.
  4. Elias J., Findlow J., Borrow R., Tremmel A., Frosch M., Vogel U. Persistence of antibodies in laboratory staff immunized with quadrivalent meningococcal polysaccharide vaccine. // J. Occup. Med.Toxicol. 2013; 4 (1): 4.

Copyright (c) 2019 Blyakher M.S., Fedorova I.M., Koteleva S.I., Ramazanova Z.K., Kombarova S.Y., Martynenko I.G., Tulskaya E.A.

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