HISTAMINLIBERATION AND CD45 DYNAMIC IN DRUG HYPERSENSITIVITY (DHS) PATIENTS

The leucocyte specific activations on the dynamic expression of CD45-antigen (CD45-test) by the flow cytometry, the leucocyte histaminliberation nonspecific and specific (to the local anaesthetics (LA)) in the DHS patients were assessed in vitro. The leucocyte activation in the DHS patients was revealed in 80% by CD45- test. Increased spontaneous leucocyte histaminliberation – in 36,4%, nonspecific stimulated – 67,7%, LA-stimulated – 27,3% pts. КСCD45 were correlated with spontaneous histaminliberation (r = – 0,46, р=0,002), stimulated histamineliberation (r = – 0,43, р=0,013) и LA-stimulated histamineliberation (r = – 0,28, p = 0,07).

CD45-test, drug hypersensitivity, local anaesthetics, histamineliberation