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The leucocyte specific activations on the dynamic expression of CD45-antigen (CD45-test) by the flow cytometry, the leucocyte histaminliberation nonspecific and specific (to the local anaesthetics (LA)) in the DHS patients were assessed in vitro. The leucocyte activation in the DHS patients was revealed in 80% by CD45- test. Increased spontaneous leucocyte histaminliberation – in 36,4%, nonspecific stimulated – 67,7%, LA-stimulated – 27,3% pts. КСCD45 were correlated with spontaneous histaminliberation (r = – 0,46, р=0,002), stimulated histamineliberation (r = – 0,43, р=0,013) и LA-stimulated histamineliberation (r = – 0,28, p = 0,07).

About the authors

Zh. P. Vasneva

Samara Diagnostic Centre

Author for correspondence.
Email: vasneva@list.ru

PhD, laborant doctor,


Russian Federation

M. V. Mokeeva

Samara Diagnostic Centre

Email: fake@neicon.ru

PhD, doctor,


Russian Federation


  1. Бровка Д. К., Юдина Н. А. Сравнительная информативность методов диагностики сенсибилизации к местным анестетикам. Медицинские новости 2015, № 11, 50–53.
  2. Зайков С. В. Современные подходы к диагностике и оказанию неотложной помощи при анафилаксии. Новости медицины и фармации 2013, № 17, 50–52.
  3. Librowski T., Pytka K., Rapacz A. Antihistaminic activity of lidocaine derivatives in the isolated guinea pig ileum. Acta biologica Cracoviencia Series Zoologia 2012, 54, 25–28.
  4. Lukawska J., Caballero M. R., Tsabouri S., Dugue P. Hypersensitivity to local an aesthetics – 6 facts and 7 myths. Current Allergy & Clinical Immunology 2009, 22(3), 117–120.
  5. Nurpeissov T., Avdugalieva A. Features of hypersensitivity to local anesthetics based on articainum in tests in vitro. Clinical and Translational Allergy 2014, 130.

Copyright (c) 2019 Vasneva Z.P., Mokeeva M.V.

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