HISTAMINLIBERATION AND CD45 DYNAMIC IN DRUG HYPERSENSITIVITY (DHS) PATIENTS


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Abstract

The leucocyte specific activations on the dynamic expression of CD45-antigen (CD45-test) by the flow cytometry, the leucocyte histaminliberation nonspecific and specific (to the local anaesthetics (LA)) in the DHS patients were assessed in vitro. The leucocyte activation in the DHS patients was revealed in 80% by CD45- test. Increased spontaneous leucocyte histaminliberation – in 36,4%, nonspecific stimulated – 67,7%, LA-stimulated – 27,3% pts. КСCD45 were correlated with spontaneous histaminliberation (r = – 0,46, р=0,002), stimulated histamineliberation (r = – 0,43, р=0,013) и LA-stimulated histamineliberation (r = – 0,28, p = 0,07).

About the authors

Zh. P. Vasneva

Samara Diagnostic Centre

Author for correspondence.
Email: vasneva@list.ru

PhD, laborant doctor,

Samara

Russian Federation

M. V. Mokeeva

Samara Diagnostic Centre

Email: fake@neicon.ru

PhD, doctor,

Samara

Russian Federation

References

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  4. Lukawska J., Caballero M. R., Tsabouri S., Dugue P. Hypersensitivity to local an aesthetics – 6 facts and 7 myths. Current Allergy & Clinical Immunology 2009, 22(3), 117–120.
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Copyright (c) 2019 Vasneva Z.P., Mokeeva M.V.

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