Email this article PATHOGENETIC FEATURES OF PHENOTYPES CLUSTERS OF BRONCHIAL ASTHMA AT THE REHABILITATION STAGE
- Authors: Dudchenko L.S.1
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Affiliations:
- State Budgetary Institution of Public Health of the Republic of Crimea «Academic Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation named by I. M. Sechenov»
- Issue: Vol 22, No 4 (2019)
- Pages: 1453-1465
- Section: ORIGINAL ARTICLES
- Submitted: 20.10.2020
- Accepted: 20.10.2020
- Published: 20.12.2019
- URL: https://rusimmun.ru/jour/article/view/552
- DOI: https://doi.org/10.31857/S102872210007058-8
- ID: 552
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Abstract
Aims: to identify phenotypes of the bronchial asthma (BA) upon admission of patients for the sanatorium medical rehabilitation (SMR) using cluster analysis and to analyse their pathogenetic features. The research include 518 patients with BA who passed SMR. Survey conducted: clinical, functional, laboratory. Immunological indicators were studied: IGE, IFN-α, IFN-γ, IL-4, EGF, TGF-β, TNF. Statistical processing of material in the SPSS25 program. On the basis of results of inspection of patients with cluster analysis is BA applied and 3 clusters are selected. Diagnostic parameters for reference of patients to clusters are determined and features of immunological inspection are described. Selection of homogeneous groups at a stage of rehabilitation matters for development of the personalized programs of rehabilitation.
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About the authors
L. Sh. Dudchenko
State Budgetary Institution of Public Health of the Republic of Crimea «Academic Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation named by I. M. Sechenov»
Author for correspondence.
Email: vistur@mail.ru
PhD (Medicine),
Yalta city, Republic of Crimea, Mukhina street 10/3
Russian FederationReferences
- Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Update 2017. http://www.ginasthma.org Acessed December, 2018.
- Ненашева Н. М. Бронхиальная астма. Современный взгляд на проблему. М.: ГЭОТАР-Медиа; 2018.
- Wenzel S. Asthma phenotypes: the evolution from clinical to molecular approaches. Nature Medicine.2012; 18: 716–725. doi: 10.1038/nm.2678
- Moore W. C., Meyers D. A., Wenzel S. E. et al. Wen Identifi cation of asthma phenotypes using cluster analysis in the severe asthma research program. Am. J. Respir. Crit. CareMed. 2010; 181(4): 315–323. doi: 10.1164/rccm.200906-0896OC.
- Haldar P., Pavord I. D., Shaw D. E. et al. Cluster analysis and clinical asthma phenotypes. Am. J. Respir. Crit. CareMed. 2008; 178: 218–224. doi: 10.1164/rccm.200711-1754OC.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).