Chronic inflammation and stress-hormones: a common pathway of cognitive disorders in ageing

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Here we present the data on examining inter-connections cytokine network and stress hormones in senile vascular dementia by assessing systemic cytokine levels for IL-1β, IL-6, IL-10, TNFα, IFNγ as well as hormones cortisol, adrenocorticotropic hormone (ACTH), epinephrine, norepinephrine and dopamine in 23 subjects with vascular dementia and 40 individuals without overt cognitive impairment. It was found, that the concentrations of IL-6, TNFα, epinephrine and dopamine were significantly increased, whereas those for IL-1β, IL-10, ACTH and norepinephrine were decreased in elderly people with dementia compared to healthy aging. In addition, virtually no inter-connection between cytokine, sympathoadrenal and hypothalamicpituitary (HPA-axis) axis was observed in vascular dementia highlighted by no significant correlation within the cytokine network. However, a single positive intrahormonal link for cortisol-ACTH and two positive links between IFNγ and cortisol/adrenaline level were detected. In general, vascular dementia was featured by marked inflammatory reaction, excessive activation of stress hormone production and disconnection of cytokine network, HPA-axis and the sympathoadrenal medullary system.

About the authors

Yu. Yu. Filippova

Chelyabinsk State University

Author for correspondence.

Filippova Yuliya Yu. - PhD (Biology), Associate Professor, Department of Microbiology, Immunology and General Biology, Faculty of Biology

454001, Chelyabinsk, Br. Kashirin str., 129

Phone: 7 (351) 799-71-76

Russian Federation

A. L. Burmistrova

Chelyabinsk State University


PhD, MD (Medicine), Professor, Head, Department of Microbiology, Immunology and General Biology, Faculty of Biology


Russian Federation


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Copyright (c) 2020 Filippova Y.Y., Burmistrova A.L.

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