INFLUENCE OF GLUTAMIL-TRIPTOFAN ON THE EXPRESSION OF IL-8 AND ICAM-1 MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY 926 LINE

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Abstract

The aim of the study was to investigate the cell mechanisms mediating immunomodulatory effects of a-glutamyl-tryptophan (EW) and estimate the possibility of this pharmaceutical agent to impact the level of NF-kp phosphorylation. Using in vitro model of inflammation, we tested whether EW impacts spontaneous and TNFa induced IL-8 secretion as well as ICAM-1 expression by endothelial EA.hy 926 cells and mononuclear leukocytes of human peripheral blood. Revealed inhibition of pro-inflammatory cytokine production can contribute to anti-inflammatory effects of EW. However a capability of EW to increase ICAM-1 expression suggests its cell activating function. Thus, due to diverse effects it seems unlikely that EW influences NF-kp directly.

About the authors

T. A. Kudryavtseva

ZAO "MBNPK "Cytomed"

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

E. A. Starikova

Institute of Experimental Medicine

Email: noemail@neicon.ru
Russian Federation

N. A. Aktureeva

Institute of Experimental Medicine

Email: noemail@neicon.ru
Russian Federation

S. V. Petlenko

ZAO "MBNPK "Cytomed"

Email: noemail@neicon.ru
Russian Federation

V. S. Smirnov

ZAO "MBNPK "Cytomed"

Email: noemail@neicon.ru
Russian Federation

N. I. Stukan

ZAO "MBNPK "Cytomed"

Email: noemail@neicon.ru
Russian Federation

A. V. Lyovina

ZAO "MBNPK "Cytomed"

Email: noemail@neicon.ru
Russian Federation

References

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  2. Smirnov V. S. Modern drugs of prevention and treatment of influenza and acute respiratory viral infections. SPb: PHARMIndex.- 2010.- ISBN 978-5-91753-015-4.
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Copyright (c) 2017 Kudryavtseva T.A., Starikova E.A., Aktureeva N.A., Petlenko S.V., Smirnov V.S., Stukan N.I., Lyovina A.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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