THE LEVEL OF SPONTANEOUS AND ANTI-СD3-STIMULATED СD38 EXPRESSION ON T-LYMPHOCYTES IN CHILDREN WITH AUTOIMMUNE PATHOLOGY

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  • Authors: Pashnina I.A.1,2
  • Affiliations:
    1. Regional Children's Clinical Hospital № 1
    2. Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.
  • Issue: Vol 20, No 2 (2017)
  • Pages: 191-194
  • Section: Articles
  • Submitted: 22.10.2020
  • Published: 15.04.2017
  • URL: https://rusimmun.ru/jour/article/view/622
  • ID: 622

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Abstract

Children of 6-17 years old with systemic lupus erithematosus (n=10), with systemic sclerosis (n=10), with juvenile idiopathic arthritis (n=47) and conditionally healthy controls of corresponding age (n=30) were examined. It was revealed by flow cytometry that after 24-hours incubation (37 °C, 5 % СО2) the spontaneous and anti-СD3-stimulated amount of СD38-positive T-lymphocytes, T-helpers and cytotoxic T-cells in children with rheumatic diseases was decreased in comparison with healthy control.

About the authors

I. A. Pashnina

Regional Children's Clinical Hospital № 1; Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

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