INTERLEUKIN‑7

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Abstract

Interleukin 7 (IL‑7) is a protein that in humans is encoded by the IL7 gene. IL‑7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by normal lymphocytes. IL‑7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). IL‑7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre‑pro‑B cell growth‑stimulating factor. IL‑7 binds to the IL‑7 receptor, a heterodimer consisting of Interleukin‑7 receptor alpha and common gamma chain receptor. Binding results in a cascade of signals important for T‑cell development within the thymus and survival within the periphery. Knockout mice which genetically lack IL‑7 receptor exhibit thymic atrophy, arrest of T‑cell development at the double positive stage, and severe lymphopenia, increases in B and T cells.

About the authors

O. F. Eremina

I. Yevdokimov Moscow State University of Medicine and Dentistry, Research Medicine and Dentistry Institute

Author for correspondence.
Email: immunolab@mail.ru

Moscow

Russian Federation

I. P. Balmasova

I. Yevdokimov Moscow State University of Medicine and Dentistry, Research Medicine and Dentistry Institute

Email: fake@neicon.ru

Moscow

Russian Federation

M. M. Gultyaev

I. Yevdokimov Moscow State University of Medicine and Dentistry, Research Medicine and Dentistry Institute

Email: fake@neicon.ru

Moscow

Russian Federation

N. V. Gluhoedova

I. Yevdokimov Moscow State University of Medicine and Dentistry, Research Medicine and Dentistry Institute

Email: fake@neicon.ru

Moscow

Russian Federation

N. D. Yushchuk

I. Yevdokimov Moscow State University of Medicine and Dentistry, Research Medicine and Dentistry Institute

Email: fake@neicon.ru

Moscow

Russian Federation

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Copyright (c) 2018 Eremina O.F., Balmasova I.P., Gultyaev M.M., Gluhoedova N.V., Yushchuk N.D.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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