ANTIBODIES TO BENZO[A]PYRENE AND ESTRADIOL AND THE GENE POLYMORPHISMS OF CYTOKINES AT MALE LUNG CANCER

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Abstract

The associations of antibodies to benzo[a]pyrene and estradiol (IgG-Bp, IgG-Es) with IL1B(rs1143634, rs16944), IL1RN(VNTR, intron 2), IL4 (VNTR, intron3), IL6 (rs1800795), IL10 (rs1800896), TNFA (rs1800629, rs361525) gene polymorphisms in 228 smoking healthy men (NM) and 657 lung cancer patients (LCP)were studied. There was revealed association of gene polymorphism only of TNFA (rs1800629) with LC, but not others cytokines. LC risk in GG carriers was high (OR = 1,1–2,3; p = 0,007) and in GA carriers was low (OR = 0,4–0,9; p = 0,01). LC risk was low (OR = 0,3–0,7; p = 0,0002) when both IgG-Bp and IgG-Es were absent. LC risk was high (OR = 1,8–4,4; p = 0,0001) when levels both IgG-Bp and IgG-Es were increased. IgG-Bp and IgG-Es formation was associated with TNFA (rs361525) gene polymorphism in HM (p = 0,007), and with IL1RNVNTR genepolymorphism (p = 0,003) and IL1B(rs16944) (p = 0,007) in LCP. There have first reported a relationship between cytokines gene polymorphisms and specific immune responses on chemical carcinogens and endogenous steroids in healthy donors and lung cancer patients. Immunoassays of IgG antibodies to Bp and Es combined with molecular-genetic studies of TNFA (rs361525), IL1RNVNTR and IL1B (rs16944) are recommended for the lung cancer risk assessment.

About the authors

A. N. Glushkov

The Federal Research Center of Coal and Coal chemistry SBRAS (Institute of Human Ecology); Kemerovo State University

Author for correspondence.
Email: ihe@list.ru

MD, Professor, Director of Institute of Human Ecology

650065 Kemerovo, avenue Leningradsky, 10

Russian Federation

E. G. Polenok

The Federal Research Center of Coal and Coal chemistry SBRAS (Institute of Human Ecology)

Email: fake@neicon.ru

PhD (Pharmacy), Chief of Immunochemistry Laboratory of Institute of Human Ecology 

Kemerovo

Russian Federation

L. A. Gordeeva

The Federal Research Center of Coal and Coal chemistry SBRAS (Institute of Human Ecology)

Email: fake@neicon.ru

PhD (Biology), Chief of Immunogenetics Laboratory of Institute of Human Ecology

Kemerovo Russian Federation

S. A. Mun

The Federal Research Center of Coal and Coal chemistry SBRAS (Institute of Human Ecology)

Email: fake@neicon.ru

PhD (Medicine), Senior Research Fellow of the Immunogenetics Laboratory of Institute of Human Ecology

Kemerovo Russian Federation

M. V. Kostyanko

Kemerovo State University

Email: fake@neicon.ru

Leading Engineer of the Organic Chemistry Chair of Institute of Fundamental Sciences

Kemerovo Russian Federation

V. A. Titov

Regional Clinical Oncology Dispensary, Kemerovo

Email: fake@neicon.ru

Chief of Thoracic Department

Kemerovo Russian Federation

E. N. Voronina

Institute of Chemical Biology and Fundamental Medicine SB RAS

Email: fake@neicon.ru

PhD (Biology), Research Fellow of Pharmacogenomics Laboratory

Novosibirsk Russian Federation

A. I. Rogozin

Kemerovo State University

Email: fake@neicon.ru

Master of Genetics Chair of Institute of Biology, Ecology and Natural Resources

Kemerovo Russian Federation

A. I. Voloshina

Kemerovo State University

Email: fake@neicon.ru

Master of Genetics Chair of Institute of Biology, Ecology and Natural Resources

Kemerovo Russian Federation

I. A. Vafin

Regional Center of Blood, Kemerovo

Email: fake@neicon.ru

Main Physician 

Kemerovo

Russian Federation

S. E. Ragozhina

Regional Center of Blood, Kemerovo

Email: fake@neicon.ru

Assistant of Main Physician 

Kemerovo

Russian Federation

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Copyright (c) 2018 Glushkov A.N., Polenok E.G., Gordeeva L.A., Mun S.A., Kostyanko M.V., Titov V.A., Voronina E.N., Rogozin A.I., Voloshina A.I., Vafin I.A., Ragozhina S.E.

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