IMMUNOLOGICAL REACTIONS IN PATIENTS WITH LUNG TUBERCULOMA IN DIFFERENT PHASES ACTIVITY
- Authors: Berdyugina O.V.1,2, Yershova A.V.1
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Affiliations:
- Ural Research Institute of Phthisiopulmonology
- Ural State Medical University
- Issue: Vol 20, No 3 (2017)
- Pages: 363-365
- Section: Articles
- Submitted: 22.10.2020
- Published: 15.07.2017
- URL: https://rusimmun.ru/jour/article/view/686
- ID: 686
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Abstract
The purpose of the study is the definition of characteristics of the response of the immune system of patients with lung tuberculoma in the active phase and phase subsides / moderate activity for the establishment of the laboratory criteria for preoperative evaluation of educational activity. The study was performed with the participation of 160 people, We studied the absorption and functional metabolic activity of neutrophils and monocytes, population composition of cells, expression of adhesion molecules and markers of cell activity, the concentration of cytokines. Determine CD11b expression tests and HLA-DR on monocytes, CD11b - on neutrophils, evaluations populations CD3+HLA-DR+ and CD3+CD4+CD25high can be recommended for preoperative assessment of activity tuberculoma lung.
About the authors
O. V. Berdyugina
Ural Research Institute of Phthisiopulmonology; Ural State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. V. Yershova
Ural Research Institute of Phthisiopulmonology
Email: noemail@neicon.ru
Russian Federation
References
- Doherty M. T. Mycobacterium tuberculosis survival strategies. Immunotherapy. 2012, 4(6), 629-647.
- Suhail A. Pathogenesis, immunology, and diagnosis of latent Mycobacterium tuberculosis infection. Clin. and Develop. Immunol. 2011, 2011, 17.
- Yew W. W., Leung C. C. Update in tuberculosis. Am. J. Respir. Crit. Care Med. 2008, 177, 479-485.
- Jiang L. N., Yao C. Y., Jin Q. L. et al. The enhancing effect of IL-12 on phagocytosis and killing of Mycobacterium tuberculosis by neutrophils in tuberculosis patients. NCBI. 2011, 11, 1191-1194.
- Pieters J. Mycobacterium tuberculosis and the Macrophage: Maintaining a balance. Cells Horst and Microbe. 2008, 6, 399-407.