CLINICAL ROLE OF LOCAL ANTIMICROBIAL FACTORS AND CYTOKINES IN CHILDREN WITH REACTIVE ARTHRITIS

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Abstract

Significant local antimicrobial factors of the intestinal biotope and cytokines associated with the variant of the course of reactive arthritis (ReA): IL-17, IL-6, INF-γ, lysozyme, CRB have been determined, which allows them to be used as markers for predicting the course and the outcome of ReA.

About the authors

E. I. Danilova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

I. A. Nikiforov

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

O. E. Chelpachenko

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

L. P. Fedotova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

E. V. Ivanova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

N. B. Perunova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

T. A. Bondarenko

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

References

  1. Scher J. U., Littman D.R., Abramson S. B. Microbiome in inflammatory arthritis and human rheumatic diseases. Arthritis Rheumatol.2016, 68(1), 35-45.
  2. Vitetta L., Coulson S., Linnane A. W. et al. The gastrointestinal microbiome and musculoskeletal diseases: a beneficial role for probiotics and prebiotics. Pathogens 2013, 2, 606-626.
  3. O’Hara A.M., Shanahan F. Thegut flora as a forgotten organ. EMBO Rep. 2006, 7, 688-693.
  4. Челпаченко О.Е., Перунова Н.Б., Иванова Е. В. и со-авт. Локальные антимикробные факторы у детей с реактивным артритом. Российский иммунологический журнал 2016, 10(19), 2(1), 372-374.

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Copyright (c) 2017 Danilova E.I., Nikiforov I.A., Chelpachenko O.E., Fedotova L.P., Ivanova E.V., Perunova N.B., Bondarenko T.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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