FEATURES OF FORMATION OF THE MUCOSAL IMMUNITY OF THE UPPER RESPIRATORY TRACT IN PRETERM INFANTS IN THE FIRST YEAR OF LIFE

Studied parameters of local immunity of the mucous membranes of the upper respiratory tract in 47 children the first year of life, born premature. Found that in preterm infants on nasal mucosa there is transient deficiency of IgG, low levels of IgE antibodies, cytokine IF-γ in the second half of life. These features of local immunity of the nasal mucosa is most pronounced in children born at gestational age of 28-32 weeks. The tension of mechanisms of the immune response in the mucosa of the oropharynx shows the excess production of proinflammatory cytokine IL-φ throughout the first year of life, and high IgE and IgA in the first half of the year.

мукозальный иммунитет, верхние дыхательные пути, недоношенные новорожденные, mucosal immunity, upper respiratory tract, premature babies