RELATIONSHIP OF THE EFFICACY OF ULIPRISTAL ACETATE THERAPY WITH POPULATION SUBSETS OF ENDOMETRIAL MACROPHAGES OF PATIENTS WITH UTERINE LEIOMYOMA

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Abstract

The decrease of the leiomyoma size under the influence of ulipristal acetate therapy took place in women with initially high level of endometrial TGFpi+ macrophages and with elevation of TGFpi+ and CD163+ macrophages after treatment. Lack of the treatment effect was associated with diminishment of M2 macrophages and increases the amount of IL-12+ macrophages.

About the authors

S. N. Nagornii

Federal State Research Institute of Maternity and Childhood named V. N. Gorodkov

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

Yu. S. Antsiferova

Federal State Research Institute of Maternity and Childhood named V. N. Gorodkov

Email: noemail@neicon.ru
Russian Federation

D. N. Voronin

Federal State Research Institute of Maternity and Childhood named V. N. Gorodkov

Email: noemail@neicon.ru
Russian Federation

A. I. Malyshkina

Federal State Research Institute of Maternity and Childhood named V. N. Gorodkov

Email: noemail@neicon.ru
Russian Federation

A. N. Kirsanov

Federal State Research Institute of Maternity and Childhood named V. N. Gorodkov

Email: noemail@neicon.ru
Russian Federation

D. A. Malyshkina

Federal State Research Institute of Maternity and Childhood named V. N. Gorodkov

Email: noemail@neicon.ru
Russian Federation

References

  1. Малышкина А. И. Иммунные механизмы быстрого роста миомы матки / А. И. Малышкина, Н. Ю. Сотникова, Ю. С. Анциферова, А. К. Красильникова.- Иваново: ОАО «Издательство Иваново», 2010.- 272 с.
  2. Protic O., Toti P., Islam M. S., Occhini R., et al. Possible involvement of inflammatory/reparative processes in the development of uterine fibroids. Cell Tissue Res. 2016, 364 (2), 415-427.
  3. Roszer T. Understanding the mysterious M2 macrophage through activation markers and effector mechanisms. Mediators of Inflammation. Volume 2015, Article ID 816460, 16 pages
  4. Grandi G., Mueller M., Bersinger N. A., Cagnac-ci A., et al. Does dienogest influence the inflammatory response of endometriotic cells? Inflamm Res. 2016, 65(3), 183-192.

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Copyright (c) 2017 Nagornii S.N., Antsiferova Y.S., Voronin D.N., Malyshkina A.I., Kirsanov A.N., Malyshkina D.A.

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