DINAMYCS OF HUMORAL IMMUNITY INDICATORS IN PATIENTS WITH ASEPTIC NECROSIS OF THE FEMORAL HEAD

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Abstract

The level of B-lymphocytes, the major classes of Ig, circulating immune complexes(CIC) in blood of patients with aseptic necrosis of the femoral head (ANFH) before and after(in a year) total joint replacement surgery has been investigated. A significant reduction of initially high levels of IgG, CIC and b-lymphocytes after joint replacement is determined. The levels of IgG in the blood of patients with ANFH are considered as markers of the effective treatment.

About the authors

A. V. Chekushkin

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

A. A. Safronov

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

Al. A. Safronof

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

A. M. Matiyash

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

References

  1. Pouya F. Avascular Necrosis of the Femoral Head: Are Any Genes Involved? Archives of Bone and Joint Surgery / F. Pouya, M. A. Kerachian // Archives of Bone and Joint Surgery.- 2015.- V.3, N 3.-С. 149-155.
  2. Osteoimmunology: interplay between the immune system and bone metabolism / M. Walsh, N. Kim, Y. Kadono et al. //Ann. Rev. Immunol.- 2006.- V. 24.- C. 33-63.
  3. Immune complexes regulate bone metabolism through FcRγ signalling / T. Negishi-Koga, H. J. Gober, E. Sumiya et al. // Nat. Commun. - 2015. - V.31. doi: 10.1038/ncomms7637.
  4. Chen G. Y. Sterile infl ammation: sensing and reacting to damage / G. Y. Chen, G. Nunez // Nature Reviews Immunology- 2010. - V. 10, N 12. - P. 826-837.

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Copyright (c) 2017 Chekushkin A.V., Safronov A.A., Safronof A.A., Matiyash A.M.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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