Email this article EFFECT OF DEHYDROEPIANDROSTERONE ON THE LUMINOL- DEPENDENT CHEMILUMINESCENCE RESPONSE UNDER ZYMOSAN-INDUCED PERITONITIS IN OLD RATS
- Authors: Shilov S.J.1,2, Shilov J.I.1,2, Barkov S.J.2
-
Affiliations:
- Institute of Ecology and Genetics of Microorganisms of the UB RAS
- Acad. E. A. Wagner Perm State Medical University
- Issue: Vol 20, No 3 (2017)
- Pages: 570-572
- Section: Articles
- Submitted: 22.10.2020
- Published: 15.07.2017
- URL: https://rusimmun.ru/jour/article/view/773
- ID: 773
Cite item
Full Text
Abstract
It was established that level of the luminol-dependent chemiluminescence reaction in old male rats under zymosan-induced peritonitis was higher in comparison with young rats. The introduction of dehy-droepiandrosterone to the old rats results in a marked decrease in the luminol-dependent chemiluminescence with peritoneal cells.
About the authors
S. Ju. Shilov
Institute of Ecology and Genetics of Microorganisms of the UB RAS; Acad. E. A. Wagner Perm State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
Ju. I. Shilov
Institute of Ecology and Genetics of Microorganisms of the UB RAS; Acad. E. A. Wagner Perm State Medical University
Email: noemail@neicon.ru
Russian Federation
S. Ju. Barkov
Acad. E. A. Wagner Perm State Medical University
Email: noemail@neicon.ru
Russian Federation
References
- Labrie F., Luu-The V., Belanger A., Lin S-X., Si-mard J., Pelletier J., Labrie C. Is dehydroepiandros-terone a hormone? J. Endocrinol., 2005, 187 (2), 169-196.
- Koziol-White C.J., Goncharova Е. А., Сао G., Johnson М., Krymskaya V. P, Panettieri R. A. Jr. DHEA-S inhibits human neutrophil and human airway smooth muscle migration. Biochim. Biophys. Acta, 2012,1822(10), 1638-1642.
- Radford D. J., Wang K., McNelis J.C., Taylor A. E., Hechenberger G., Hofmann J., Chahal H., Arlt W., Lord J. M. Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation. Mol. Endocrinol. 2010, 24(4), 813-821. doi: 10.1210/me.2009-0390. Epub 2010 Feb 19.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).