Email this article A META-ANALYSIS OF THE RESEARCH OF THE CONCENTRATION OF IL-17 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A (H1N1) pdm09
- Authors: Shipilov M.V.1, Tutelian A.V.2
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Affiliations:
- “Clinical Hospital № 1”, Smolensk
- Federal Budget Institution of Science “Central Research Institute of Epidemiology” of The Federal Service on Customers’ Rights Protection and Human Well-being Surveillance
- Issue: Vol 21, No 1 (2018)
- Pages: 35-39
- Section: ORIGINAL ARTICLES
- Submitted: 15.04.2020
- Accepted: 15.04.2020
- Published: 15.01.2018
- URL: https://rusimmun.ru/jour/article/view/78
- DOI: https://doi.org/10.7868/S1028722118010045
- ID: 78
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Abstract
Interleukin‑17 (IL‑17) is one of the inflammatory cytokines, which enhances including the effects of other pro‑inflammatory cytokines. In order to increase the statistical power and increase the reliability of the results according to various researchers, including as a result of its own research, conducted a meta‑analysis (a quantitative systematic review) study of IL‑17 in peripheral blood of patients with influenza A (H1N1) pdm09. Question: to determine with a high level of confidence, whether IL‑17, a marker of prognosis of influenza A (H1N1) pdm09. Searches were carried out research work on this subject in a variety of electronic databases (Medline, EMBASE, the Cochrane Controlled Trials Register, and others.), in dissertations, journals, thematic reviews, conference proceedings and other sources. 3 scientific papers were selected that met the criteria for inclusion / non‑inclusion in the study (characteristic of scientific papers, diagnostic criteria, age of patients, comparable groups of patients, the presence of self‑control, comparable research methodology, statistical criterion and the total number of independent studies). Selected studies have shown sufficient uniformity (homogeneity) comparison groups. This meta‑analysis of scientific papers showed that the determination of serum IL‑17, patients with severe influenza A (H1N1) pdm09 allows a high probability of predicting a favorable outcome. At the same time, the frequent unfavorable outcome of the disease (with a probability of 90% or more) indicates the absence in the serum of patients with influenza A (H1N1) pdm09 IL‑17 (below the threshold of sensitivity of diagnostic test kits). Thus, the results of a meta‑analysis of IL‑17 level in the blood can be used in clinical medical practice for quite simple and convenient prognosis marker of influenza A (H1N1) pdm09.
Keywords
About the authors
M. V. Shipilov
“Clinical Hospital № 1”, Smolensk
Author for correspondence.
Email: mshipilov@rambler.ru
PhD (Medicine), head of the infectious department № 2
214006, Smolensk, Frunze Street 40 Russian FederationA. V. Tutelian
Federal Budget Institution of Science “Central Research Institute of Epidemiology” of The Federal Service on Customers’ Rights Protection and Human Well-being Surveillance
Email: fake@neicon.ru
Corresponding member of the Academy of Sciences of Russia, MD (Medicine), head of laboratory associated infections health care
Moscow Russian FederationReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).