COMBINATION EFFECTS OF ANTIBODIES TO BENZO[A]PYRENE, ESTRADIOL AND PROGESTERONE ONTO CONCENTRATIONS OF FEMALE SEX HORMONES IN BLOOD SERUM OF THE BREAST CANCER PATIENTS

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Abstract

Antibodies to benzo[a]pyrene, estradiol and progesterone (IgA-Bp, IgА-Es и IgA-Pg) as well as concentrations of Es and Pg were studied in the blood serum of 346 non-smoking breast cancer patients in post menopause. There were no any associations between IgA-Bp and hormones concentration. The high levels of Es and Pg were found when IgА-Es and IgA-Pg were increased correspondingly (p = 0,02 and p = 0,002). The high concentrations of Es and Pg as well as high ratio of Pg/Es were revealed when ratio IgA-Bp/IgА-Es were high (p = 0,003; p = 0,003 and p = 0,0002 correspondingly). So IgA-Bp modulated the effects of IgА-Es onto concentrations of Es and Pg as well as hormonal balance in breast cancer patients. There were no any associations between the revealed immune-endocrine effects with the tumor stages, metastases and Es/Pg receptors.

About the authors

A. N. Glushkov

The Federal Research Center of Coal and Coal chemistry of Siberian Branch of the Russian Academy of Sciences, Institute of Human Ecology; Kemerovo State University

Author for correspondence.
Email: ihe@list.ru

MD, Professor, Director of Institute of Human Ecology of FRC CCC SB RAS

650065 Kemerovo, avenue Leningradsky, 10 Russian Federation

E. G. Polenok

The Federal Research Center of Coal and Coal chemistry of Siberian Branch of the Russian Academy of Sciences, Institute of Human Ecology

Email: fake@neicon.ru

PhD (Candidate of Pharmacy), Chief of Immunochemistry Laboratory of Institute of Human Ecology of FRC CCC SB RAS 

Kemerovo

Russian Federation

M. V. Kostyanko

Kemerovo State University

Email: fake@neicon.ru

Leading Engineer of the Department of Organic Chemistry of Faculty of Chemistry 

Kemerovo

Russian Federation

A. I. Rogozin

The Federal Research Center of Coal and Coal chemistry of Siberian Branch of the Russian Academy of Sciences, Institute of Human Ecology

Email: fake@neicon.ru

Postgraduate of Institute of Human Ecology of FRC CCC SB RAS

Kemerovo

Russian Federation

A. V. Antonov

Regional clinical oncology hospital, Kemerovo

Email: fake@neicon.ru

Chief of Mammology Department

Kemerovo

Russian Federation

N. E. Verzhbitskaya

Pathologoanatomic bureaus, Kemerovo

Email: fake@neicon.ru

PhD (Candidate of Medicine), Chief of Pathologoanatomical Department 

Kemerovo Russian Federation

References

  1. Rundle A., Tang D., Hibshoosh H., Estabrook A., Schnabel F., Cao W., Grumet S., Perera F.P. The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer. Carcinogenesis 2000, 21(7), 1281–1289.
  2. Santella R.M., Gammon M.D., Zhang Y.J., Motykiewicz G., Young T.L., Hayes S.C., Terry M.B., Schoenberg J.B., Brinton L.A., Bose S., Teitelbaum S.L., Hibshoosh H. Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue. Cancer Lett. 2000, 154(2), 143–149.
  3. Ambrosone C.B., Abrams S.M., Gorlewska-Roberts K., Kadlubar F.F. Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells. Arch. Biochem.Biophys. 2007, 464(2), 169–175.
  4. Gammon M.D., Santella R.M., Neugut A.I., Eng S.M., Teitelbaum S.L., Paykin A., Levin B., Terry M.B., Young T.L., Wang L.W., Wang Q., Britton J.A., Wolff M.S., Stellman S.D., Hatch M., Kabat G.C., Senie R., Garbowski G., Maffeo C., Montalvan P., Berkowitz G., Kemeny M., Citron M., Schnabel F., Schuss A., Hajdu S., Vinceguerra V. Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiol. Biomarkers Prev. 2002, 11(8), 677–685.
  5. Gammon M.D., Sagiv S.K., Eng S.M., Shantakumar S., Gaudet M.M., Teitelbaum S.L., Britton J.A., Terry M.B., Wang L.W., Wang Q., Stellman S.D., Beyea J., Hatch M., Kabat G.C., Wolff M.S., Levin B., Neugut A.I., Santella R.M. Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysis. Arch. Environ. Health. 2004, 59(12), 640–649.
  6. Sagiv S.K., Gaudet M.M., Eng S.M., Abrahamson P.E., Shantakumar S., Teitelbaum S.L., Bell P., Thomas J.A., Neugut A.I., Santella R.M., Gammon M.D. Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancer. Environ. Res. 2009, 109(3), 287–291.
  7. Gaikwad N.W., Yang L., Pruthi S., Ingle J.N., Sandhu N., Rogan E.G., Cavalieri E.L. Urine biomarkers of risk in the molecular etiology of breast cancer. Breast Cancer (Auckl).2009, 3, 1–8.
  8. Pruthi S., Yang L., Sandhu N.P., Ingle J.N., Beseler C.L., Suman V.J., Cavalieri E.L., Rogan E.G. Evaluation of serum estrogen-DNA adducts as potential biomarkers for breast cancer risk. J. Steroid Biochem. Mol. Biol. 2012, 132(1–2), 73–79.
  9. Cavalieri E.L., Rogan E.G., Zahid M. Critical depurinating DNA adducts: Estrogen adducts in the etiology and prevention of cancer and dopamine adducts in the etiology and prevention of Parkinson’s disease. Int. J. Cancer. 2017, 141(6), 1078–1090.
  10. Grova N., Prodhomme E.J., Schellenberger M.T., Farinelle S., Muller C.P. Modulation of carcinogen bioavailability by immunisation with benzo[a] pyrene – conjugate vaccines. Vaccine 2010, 27(31), 4142–4151.
  11. Černohorská H., Klimešová S., Lepša L., Jinoch P., Milcová A., Schmuczerová J., Topinka J., Lábaj J. Influence of immunization with non-genotoxic PAH-KLH conjugates on the resistance of organisms exposed to benzo[a]pyrene. Mut. Res. 2012, 742(1– 2), 2–10.
  12. Sundaram K., Tsong Y.Y., Hood W., Brinson A. Effect of immunization with estrone-protein conjugate in rhesus monkeys. Endocrinology 1973, 93(4), 843–847.
  13. Schwartz U., Dyrenfurth I., Khalaf S., VandeWiele R.L., Ferin M. A comparison of the effects of active immunization of female rhesus monkeys to estradiol-17 or progesterone-20-protein conjugates. J. Steroid Biochem. 1975, 6(3–4), 541–545.
  14. Hillier S.G., Groom G.V., Boyns A.R., Cameron E.H. Effects of active immunisation against steroids upon circulating hormone concentrations. J. Steroid Biochem. 1975, 6(3–4), 529–535.
  15. Caldwell B.V., Tillson S.A., Esber H., Thorneycroft I.H. Survival of tumors after immunization against estrogens. Nature 1971, 231(14), 118–119.
  16. Глушков А.Н., Поленок Е.Г., Костянко М.В., Антонов А.В., Вержбицкая Н.Е., Вафин И.А., Рагожина С.Е. Влияние антител к эстрадиолу и прогестерону на содержание этих гормонов в сыворотке крови у здоровых женщин и больных раком молочной железы. Российский иммунологический журнал 2017, 11(20), 1, 26– 34.
  17. Charles G.D., Bartles M.J., Zacharewski T.R., Gollapudi B.B., Freshour N.L., Carney E.W. Activity of benzo[a]pyrene and its hydroxylated metabolites in an estrogen receptor-alpha reporter gene assay. Toxicol. Sci. 2000, 55(2), 320–326.
  18. Hirose T., Morito K., Kizu R., Toriba A., Hayakawa K., Ogawa S., Inoue S., Muramatsu M., Masamune Y. Estrogenic/antiestrogenic activities of benzo[a]pyrene monohydroxy derivatives. J. Health Sci. 2001, 47(6), 552–558.
  19. Chen Z., Zhang Y., Yang J., Jin M., Wang X.W., Shen Z.Q., Qiu Z., Zhao G., Wang J., Li J.W. Estrogen promotes benzo[a]pyrene-induced lung carcinogenesis through oxidative stress damage and cytochrome c-mediated caspase-3 activation pathway in female mice. Cancer. Lett. 2011, 308(1), 14–22.
  20. Lin S., Lin C.J., Hsieh D.P., Li L.A. ERα phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells. Lung Cancer 2011, 75(3), 285–292.
  21. Bennion B.J., Cosman M., Lightstone F.C., Knize M.G., Montgomery J.L., Bennett L.M., Felton J.S., Kulp K.S. PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor. Chem. Res. Toxicol. 2005, 18(10), 1528–1536.
  22. Глушков А.Н., Поленок Е.Г., Аносова Т.П., Савченко Я.А., Баканова М.Л., Минина В.И., Мун С.А., Ларин С.А., Костянко М.В. Сывороточные антитела к бензо[a]пирену и хромосомные аберрации в лимфоцитах периферической крови у рабочих углеперерабатывающего предприятия. Российский иммунологический журнал 2011, 5(14), 1, 39–44.
  23. Mohammed H., Russell I.A., Stark R., Rueda O.M., Hickey T.E., Tarulli G.A., Serandour A.A., Birrell S.N., Bruna A., Saadi A., Menon S., Hadfield J., Pugh M., Raj G.V., Brown G.D., D’Santos C., Robinson J.L., Silva G., Launchbury R., Perou C.M., Stingl J., Caldas C., Tilley W.D., Carroll J.S. Progesterone receptor modulates ERα action in breast cancer. Nature 2015, 523(7560), 313–317.
  24. Федотчева Т.А., Шимановский Н.Л. Роль гестагенов и антигестагенов в регуляции пролиферативной активности клеток рака молочной железы. Вопросы биологической, медицинской и фармацевтической химии 2005, 3, 3–11.

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Copyright (c) 2018 Glushkov A.N., Polenok E.G., Kostyanko M.V., Rogozin A.I., Antonov A.V., Verzhbitskaya N.E.

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