Immunological features of reactive arthritis depending on the inflammatory activity

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Abstract

The analysis of the immune status in 150 patients with reactive arthritis (ReA) depending on the infl ammatory activity of the disease was carried out. A statistically signifi cant inhibition of T-dependent reactions (CD3+-, CD8+- and CD4+), inhibition of neutrophil phagocytic activity, increase in blood proinfl ammatory cytokines (TNF-α, IFN-γ, IL-8) is directly proportional to the increase in the degree of disease activity. Increased content of CD20+, CIC, IgA and Ig M. There is an imbalance of cytokines and the dependence of their concentrations on the degree of infl ammatory activity of ReA, with an increase in which the content of IL-6, TNF-α, IFN-γ increases in direct proportion, which should be taken into account in the therapy.

About the authors

M. . Zhuravleva

Orenburg State Medical University

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

References

  1. Фоломеева О. М., Галушко Е. А., Эрдес Ш. Ф. Распространенность ревматических заболеваний в популяциях взрослого населения России и США. На уч но-практическая ревматология 2008, 4, 4–14.
  2. Балабанова Р. М., Дубинина Т. В., Демина А. Б., Кричевская О. А. Заболеваемость болезнями костно-мы шечной системы в Российской Федерации за 2015–2016 гг. Научно-практическая ревматология 2018, 56 (1), 15–21.
  3. Hannu T. et al. Reactive arthritis or postinfectious arthritis? Best Pract Res Clin Rheumatol. 2006, 20 (3), 419.
  4. Kwiatkowska B., Filipowicz-Sosnowska A. Reactive arthritis. Pol Arch Med Wewn. 2009, 119 (1–2), 60–5.
  5. Carter J. D., Hudson A. P. Reactive arthritis: clinical aspects and medical management. Rheum. Dis. Clin. North Am. 2009, 35 (1), 21–44.
  6. Kim T. H., Uhm W. S., Inman R. D. Pathogenesis of ankylosing spondylitis and reactive arthritis. Curr Opin Rheumatol. 2005, 17 (4), 400–5.
  7. Chou C. T., Huo A. P., Chang H. N. Cytokine production from periphera l blood mononuclear cells in patients with ank ylosing spondylitis and their fi rst-degree relatives. Arch. Med.Res. 2007, 38 (1),190–195.
  8. Гапонова Т. В., Лила А. М., Шемеровская Т. Г., Захарова Г. А., Масляева Т. Н. Изучение цитокинового статуса больных реактивным артритом Медицинская иммунология 2008, 2, 167–172.
  9. Mertz Andreas K. N., Wu Peihua, Sturniolo Tiziana, et al.
  10. Multispecifi c CD4+ T Cell Response to a Single 12-mer
  11. Epitope of the Immunodominant Heat-Shock Protein
  12. of Yersinia enterocolitica in Yersinia-Triggered Reactive Arthritis: Overlap with the B27– Restricted CD8 Epitope, Functional Properties, and Epitope Presentation by Multiple DR Alleles. J Immunol 2000, 164, 1529–1537.
  13. Locht H. et al. Characterisation of autoantibodies to neutrophil granule constituents among patients with reactive arthritis, rheumatoid arthritis, and ulcerative colitis. Ann Rheum Dis. 2000, 59 (l1), 898–903.
  14. Melles H. H., Colombo S., Linhares I. M. Evaluation of parameters for laboratory diagnosis of genital female infection by Chlamydia trachomatis. Rev Soc Bras Med Trop. 2000, 33 (4), 355–61.
  15. Журавлева М. О. Изменения содержания цитокинов у больных реактивным артритом при терапии потенцированными антителами к фактору некроза опухоли-α. Российский иммунологический журнал 2017, 11 (20), 2, 310–312.
  16. Meador R., Hsia E., KitumnuaypongvT., Schumacher H. R. TNF involvement and anti-TNF therapy of reactive and unclassifi ed arthritis // Clin. Exp. Rheumatol., 2002, 20, 6, 130–134.
  17. Meador R., Hsia E., KitumnuaypongvT., Schumacher H. R. TNF involvement and anti-TNF therapy of reactive and unclassifi ed arthritis // Clin. Exp. Rheumatol., 2002, 20, 6, 130–134.

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