Prediction of papillomavirus infection by after therapy of women and men from family couples

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Abstract

An important role in carcinogenesis in both women and men is played by the immune system. With a high established classifi cation accuracy by the method of discriminant analysis was revealed that in women from married couples with HPV VKR the fi nal function allows to determine the prognosis of the eff ectiveness of the elimination of the virus after the treatment as a result of substituting the value of the functional reserve of neutrophils of cervical mucus in the function, while the fi nal result is compared with the values of centroids 1.163 and –0.263, i. e. at a higher value of the last HPV, stimulation is not detected (p <0.002). In men from married couples, when substituting in the analogous formula the functions of the absolute neutrophil viability, the functional reserve of the neutrophils of the ejaculate, and the viral load, the centroid values fi t into the values 11,700 and –1,003 and the HPV of stimulation is not detected at a higher value of the fi nal result (p <0.001).

About the authors

D. . Markeeva

South Ural State Medical University

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

L. . Telesheva

South Ural State Medical University

Email: noemail@neicon.ru
Russian Federation

O. . Lysenko

South Ural State Medical University

Email: noemail@neicon.ru
Russian Federation

E. . Baisakalova

South Ural State Medical University

Email: noemail@neicon.ru
Russian Federation

References

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  2. Garolla A., Pizzol D., Vasoin F., et al. Counseling reduces HPV persistence in coinfected couples. J Sex Med. 2014. 11(1), 127–35.
  3. Абрамовских О. С., Телешева Л. Ф., Долгушина В. Ф. Иммунологические критерии прогноза течения цервикальной патологии, ассоциированной с папилломавирусной инфекцией. Иммунопатология, аллергология, инфектология. 2015. 3. 8–13. [Abramovskikh O. S., Telesheva L. F., Dolgushina V. F. Immunological criteria for predicting the course of cervical pathology associated with papillomavirus infection. Immunopathology, allergology, infectology. 2015. 3, 8–13.]
  4. Лысенко О. В., Телешева Л. Ф., Троянова А. В. Папилломавирусная инфекция у семейных пар: заметки к теме. Современные проблемы дерматовенерологии, иммунологии и врачебной косметологии. 2013.. 8. 3 (26), 49–55. [Lysenko O. V., Telesheva L. F., Troyanova A. V. Papillomavirus infection in married couples: notes to the topic. Modern problems of dermatovenereology, immunology and medical cosmetology. 2013. 8(3), (26), 49–55].
  5. Kang M., Lagakos S. W. Statistical methods for panel data from a semi-Markov process, with application to HPV // Biostatistics. 2007. Т. 8(2). Р.:252–64.

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