Email this article Influence of macrophage modulation on the state of extra islet insulin-producing system in hypergycemia
- Authors: Sokolova K..1,2, Belousova A..1, Gette I..1,2, Danilova I..1,2, Abidov M..2
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Affiliations:
- Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B.N. Yeltsin
- Issue: Vol 21, No 3 (2018)
- Pages: 439-443
- Section: ORIGINAL ARTICLES
- Submitted: 22.10.2020
- Published: 15.07.2018
- URL: https://rusimmun.ru/jour/article/view/908
- DOI: https://doi.org/10.31857/S102872210002424-1
- ID: 908
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Abstract
Restoring of insulin-synthesizing cell pool by means of macrophage activity modulation can be a promising direction in the treatment of diabetes mellitus. Modeling of type 2 diabetes mellitus in rats (110 mg / kg of nicotinamide and 65 mg / kg of streptozotocin) caused a spontaneous compensatory increase in the number of extra islet insulin-producing cells up to 30 days, followed by a decrease in the number of these cells by 60 days without enhancing their functional activity. Modulation of macrophage activity with the administration of aminophthalhydrazide (2 mg / kg, 20 injections) to diabetic rats was accompanied by an increase in the number of the extra islet insulin-producing cells, the accumulation of insulin in all the studied groups of these cells, and a reduction in hyperglycemia.
About the authors
K. . Sokolova
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B.N. Yeltsin
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. . Belousova
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
I. . Gette
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: noemail@neicon.ru
Russian Federation
I. . Danilova
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: noemail@neicon.ru
Russian Federation
M. . Abidov
Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: noemail@neicon.ru
Russian Federation
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).