THE IMMUNOLOGICAL PREDICTORS OF THE INEFFICIENCY FIRST LINE THERAPY AT THE PRIMARY OPEN-ANGLE GLAUCOMA



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Abstract

The primary open-angle glaucoma is a first in disability among eye diseases. First-line drugs – prostaglandin analogues are not always effective. The aim of the work was the search for predictors of the ineffectiveness of this therapy. The cytokines TNF-α, TNF-β, IL4, IL-6, IL-10, IL-13, IL-17, IL-22, IL-29, IFN-γ, TGF-α, TGF-β1, TGF -β2 was investigated in the tear fluid of 124 eyes in the diagnosis of glaucoma. Predictors of non-compensation of intraocular pressure when prescribing prostaglandin drugs is a high level of IL-17 and a decrease in TGF-β2. The high level of IL-6 is a predictor of a decrease in visual function during prostaglandin therapy.

About the authors

A. S. Kuznetsov

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Author for correspondence.
Email: agent_zebrovich@mail.ru

postgraduate student of Department of normal and pathological physiology,

Vladivostok

Russian Federation

A. S. Khokhlova

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

postgraduate student of Department of normal and pathological physiology,

Vladivostok

Russian Federation

E. V. Markelova

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

PhD, head of theDepartment of normal and pathological physiology,

Vladivostok

Russian Federation

M. S. Urbanova

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

resident of Department of ophthalmology and otorhinolaryngology, 

Vladivostok

Russian Federation

N. P. Emeiyanova

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

student,

Vladivostok

Russian Federation

A. A. Petrov

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

student,

Vladivostok

Russian Federation

References

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  2. Симбирцев А. С. Роль цитокинов в развитии опухолей и в иммунотерапии рака. В кн.: Цитокины в патогенезе и лечении заболеваний человека. Фолиант, СПб 2018, 187–188.
  3. Duvesh R., Puthuran G., Srinivasan K. Multiplex Cytokine Analysis of Aqueous Humor from the Patients with Chronic Primary Angle Closure Glaucoma. Current Eye Research. 2017, 42, 1608–1613.
  4. Gupta D., Wen J., Huebner J. Cytokine biomarkers in tear film for primary open-angle glaucoma. Clinical Ophthalmology, 2017, 11, 411–416.
  5. Li T. Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis. Ophthalmology, 2016, 123(1), 129–140.

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Copyright (c) 2019 Kuznetsov A.S., Khokhlova A.S., Markelova E.V., Urbanova M.S., Emeiyanova N.P., Petrov A.A.

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