APPLICATION OF IN VITRO CULTURAL MODELS WITH INTERLEUKIN-7 FOR ESTIMATING THE FUNCTIONAL ACTIVITY OF T-LYMPHOCYTES


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Abstract

Currently, studies on the action of cytokines on the functional activity of immunocompetent cells are of great scientific interest. The most signifi ant is the use of various models of the immune system cells culture. This paper describes two cellular models used to study the direct effect of interleukin-7 on the functional properties of T-lymphocytes. Interleukin-7 (IL-7) is involved in the main stages of the T-cell life cycle: carrying out the signals necessary for survival, differentiation, proliferative activity, protection from apoptotic death, homeostatic maintenance of the number of T-lymphocytes. The directionality and severity of the effects of IL-7 was evaluated on the proposed homeostatic and activation T-cell models in vitro.

About the authors

V. A. Shmarov

Immanuel Kant Baltic Federal University

Author for correspondence.
Email: enant@list.ru

Junior research fellow, Center for Medical Biotechnologies,

Kaliningrad

Russian Federation

A. G. Goncharov

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

PhD, Deputy Director of the Medical Institute for Scientific Work,

Kaliningrad

Russian Federation

References

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  2. Belarif L., Vanhove B., Poirier N. Full antagonist of the IL-7 receptor suppresses chronic inflammation in nonhuman primate models by controlling antigen-specific memory T cells. Cell Stress. 2018; 2(12), 362–364.
  3. Inokuma M. S., Maino V. C., Bagwell C. B. Probability state modeling of memory CD8+ T-cell diff erentiation.J Immunol Methods. 2013; 397(1–2), 8–17.
  4. Shmarov V. A., Malashchenko V. V., Meniailo M. E., Gaza tova N. D., Todosenko N. M., Melashchenko O. B., Goncharov A. G., Seledtsov V. I. Direct effects of interleukin-7 on the function of human T cells in vitro.Eur Cytokine Netw. 2016; 27(4), 102–107.

Copyright (c) 2019 Shmarov V.A., Goncharov A.G.

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