THE ROLE OF THREE-DIMENSIONAL MATRICES IMITATING BONE TISSUE REGENERATION IN THE FORMATION OF HEMATOPOIETIC STEM CELLS POOL UNDER IN VITRO CULTIVATION CONDITIONS



Cite item

Full Text

Abstract

The study is devoted to the search criteria for creating new bioresorbable materials that form hematopoietic stem cell niches that provide vascularization of regenerating bone tissue. In the experiment, it was revealed that the formation of hematopoietic stem cells pool under in vitro cultivation conditions depends on the surface roughness index of the artificial matrix.

About the authors

L. S. Litvinova

Immanuel Kant Baltic Federal University

Author for correspondence.
Email: fake@neicon.ru

Doctor of Medical Science, Head of the Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

K. A. Yurova

Immanuel Kant Baltic Federal University

Email: kristina_kofanova@mail.ru

Ph.D., Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

V. V. Shupletsova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Ph.D., Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

O. G. Khaziakhmatova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Ph.D., Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

E. S. Melashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Biologist of the Center for Medical Biotechnology,

Kaliningrad

Russian Federation

V. V. Malashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher, Center for Medical Biotechnologies,

Kaliningrad

Russian Federation

E. O. Shunkin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Engineer Researcher Basic Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

Y. P. Sharkeev

Institute of Strength Physics and Materials Science SB RAS

Email: fake@neicon.ru

Doctor of Physics and Mathematics, Professor, Head of Laboratory of Physics of nanostructured biocomposites,

Tomsk

Russian Federation

E. G. Komarova

Institute of Strength Physics and Materials Science SB RAS

Email: fake@neicon.ru

Ph.D., Junior Researcher, Laboratory of Physics of Nanostructured Biocomposites,

Tomsk

Russian Federation

M. B. Sedelnikova

Institute of Strength Physics and Materials Science SB RAS

Email: fake@neicon.ru

Doctor of Technical Science, Doctor of Technical Sciences Senior Researcher, Laboratory of Physics of Nanostructured Biocomposites,

Tomsk

Russian Federation

I. K. Norkin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Ph.D., student,

Kaliningrad

Russian Federation

K. I. Prokin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

student,

Kaliningrad

Russian Federation

P. A. Ivanov

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

I. A. Khlusov

Siberian State Medical University

Email: fake@neicon.ru

Ph.D., Professor of the Department of Morphology and General Pathology,

Tomsk

Russian Federation

References

  1. Dellatore S. M., Garcia A. S., Miller W. M. Mimicking stem cell niches to increase stem cell expansion //Current opinion in biotechnology, 2008, 19 (5), P. 534–540.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2019 Litvinova L.S., Yurova K.A., Shupletsova V.V., Khaziakhmatova O.G., Melashchenko E.S., Malashchenko V.V., Shunkin E.O., Sharkeev Y.P., Komarova E.G., Sedelnikova M.B., Norkin I.K., Prokin K.I., Ivanov P.A., Khlusov I.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies