Translation into Russian of the Classification of inborn errors of immunity in humans updated by experts from a Committee on Congenital Immunity Errors of International Union of Immunological Societies (Russian version 2019)

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Abstract

We present to Russian-speaking audience a translation and commentary on the classification of inborn errors of immunity presented at the end of 2019 by the Committee on Congenital Immunity Errors at the International Union of Immunological Societies (IUIS). Inborn errors of immunity, or, as they were called earlier, primary immunodeficiencies, is a rapidly expanding class of diseases that includes the most diverse congenital pathologies which can manifest at any age by heterogenous symptomes. Clinical masks characterize these diseases, hence the time from the onset of clinical disorder to the final diagnosis may take many years. A doctor of any specialty encounters these patients, and the molecular mechanisms of pathology concern different organs and systems of the patients. The classification consists of ten tables covering more than 400 syndromes and their corresponding genes, or associated chromosomal abnormalities. This is a tool, which allows navigating a wide variety of different primary immunodeficiencies, autoimmune and autoinflammatory syndromes, complement defects, and bone marrow failure syndromes. We hope that, due to translation, current knowledge about these various diseases will become more close and available to the Russian-speaking audience.

About the authors

M. A. Bolkov

Research Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences;
Ural State Law University, Ekaterinburg

Email: antanariva@gmail.com
ORCID iD: 0000-0003-2763-9907

PhD (Medicine), Senior Research Associate, Research Institute of Immunology and Physiology; Associate Professor, Ural State Law University

Ekaterinburg

Russian Federation

I. A. Tuzankina

Research Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences;
Institute of Chemical Engineering, B. Yeltsin Ural Federal University

Author for correspondence.
Email: ituzan@yandex.ru
ORCID iD: 0000-0001-7496-0950

Tuzankina Irina A., PhD, MD (Medicine), Professor, Honored Scientist of the Russian Federation, Main Research Associate, Research Institute of Immunology and Physiology; Leading Research Associate, Institute of Chemical Engineering, B. Yeltsin Ural Federal University

620049, Ekaterinburg, Pervomayskaya str., 106.

Russian Federation

Kh. Shinwari

Institute of Chemical Engineering, B. Yeltsin Ural Federal University

Email: khybershinwari05@gmail.com
ORCID iD: 0000-0002-9800-2797

Shinwari Khyber, Postgraduate Studen

Ekaterinburg

Russian Federation

D. A. Cheremokhin

Research Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences

Email: dimacheremokhin@gmail.com
ORCID iD: 0000-0002-3334-2221

Postgraduate Student

Ekaterinburg

Russian Federation

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Copyright (c) 2021 Bolkov M.A., Tuzankina I.A., Shinwari K., Cheremokhin D.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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