Email this article THE ROLE OF FOOD HYPERREACTIVITY AND INTESTINAL MICROBIOTA IMBALANCE IN THE DEVELOPMENT OF METABOLIC SYNDROME IN YOUNG VOLUNTEERS
- Authors: Cherevko N.A.1, Novikov P.S.2, Murzintseva A.A.2, Vlasyuk E.V.1, Vekovtsev A.A.3, Bylin P.G.3, Kondakov S.E.4, Rozenshteyn M.Y.5, Rozenshteyn A.Z.5, Novikova E.A.1
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Affiliations:
- Federal State Budgetary Educational Institution of Higher Education "Siberian State Medical University" of the Ministry of Health of the Russian Federation, Tomsk, Russia
- Center for Family Medicine, Tomsk, Russia
- Scientific and Production Association "ArtLife"", Tomsk city, Russia
- Moscow State University M.V. Lomonosov Moscow, Russia
- ImmunoHealth- RUS, Moscow
- Section: SHORT COMMUNICATIONS
- Submitted: 07.01.2025
- Accepted: 24.07.2025
- URL: https://rusimmun.ru/jour/article/view/17088
- DOI: https://doi.org/10.46235/1028-7221-17088-TRO
- ID: 17088
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Abstract
Abstract
The prevalence of metabolic syndrome in the world is 20-40%. Due to the high prevalence of metabolic syndrome, its early detection is of great importance for the timely initiation of prevention of complications. Researchers still do not have a consensus on the ethology, diagnosis and treatment of metabolic syndrome. At the moment, it has only been shown that there are risk factors for the development of metabolic syndrome such as genetics, lifestyle and disorder of the normal qualitative and quantitative composition of the microbiota. In our opinion, chronic sluggish inflammation and microbiological intestinal dysbiosis play an important role in the development of metabolic disorders, and the key predictor of their development is the state of food hyperreactivity. The aim of the work was to assess the role of food hyperreactivity in the development of chronic inflammation, metabolic disorders, intestinal dysbiosis and the relationship of microbiota with inflammation indicators and metabolic disorders. To achieve the goal, specific IgG antibodies to 111 food antigens were determined using the immunohealth methodology (RZN 2020/9970), biochemical indicators of lipid and carbohydrate metabolism, proinflammatory cytokines (IL-6, IL-17), a complete blood count and 33 indicators of intestinal microbiota using PCR (Colonoflor-16, premium) were determined. The study included 60 patients with an increased body mass index and 20 volunteers with a normal body mass index. The study material included venous blood samples and fecal samples. The concentrations of cytokines, insulin, and biochemical indicators were determined in the blood serum. Fecal samples were used to assess the qualitative and quantitative composition of the colon microbiota. We obtained data indicating the role of food hyperreactivity in the development of chronic inflammation and metabolic disorders. We also showed the role of individual representatives of the intestinal microbiota and their relationship with inflammation and the development of metabolic disorders. Thus, we demonstrated an integral relationship between food hyperreactivity, intestinal microbiological dysbiosis, inflammation indicators and markers of metabolic disorders. These data can form the basis for new ways of preventing and correcting metabolic syndrome, as well as for further study in the field of microbiota in various conditions.
About the authors
Natalya Anatolyevna Cherevko
Federal State Budgetary Educational Institution of Higher Education "Siberian State Medical University" of the Ministry of Health of the Russian Federation, Tomsk, Russia
Email: chna@0370.ru
SPIN-code: 7291-1102
DSc (Medicine), MD, Immunology&Allergy Dept Professor, Siberian State Medical University
Russian Federation, 634055, Moskovsky tract, 2, Tomsk, Russia;Pavel Sergeevich Novikov
Center for Family Medicine, Tomsk, Russia
Email: pavel.n1234@yandex.ru
SPIN-code: 4510-5124
Clinical laboratory diagnostics doctor, Head of the Clinical Diagnostic Laboratory of the Medical Association “Center for Family Medicine”
Russian Federation, 634009, st. Voikova, 55, Tomsk, RussiaAlina Andreevna Murzintseva
Center for Family Medicine, Tomsk, Russia
Email: maag@0370.ru
family medicine doctor, ultrasound doctor, head of the day hospital “Center for Family Medicine”
Russian Federation, 634009, st. Voikova, 55, Tomsk, Russia;Ekaterina Viktorovna Vlasyuk
Federal State Budgetary Educational Institution of Higher Education "Siberian State Medical University" of the Ministry of Health of the Russian Federation, Tomsk, Russia
Email: ekaterina.vlasyuk5@gmail.com
6th year student of the medical and biological faculty of the Siberian State Medical University
Russian Federation, 634055, Moskovsky tract, 2, Tomsk, Russia;Andrey Alekseevich Vekovtsev
Scientific and Production Association "ArtLife"", Tomsk city, Russia
Email: andrey@artrlife.ru
Candidate of Medical Sciences, Director for Science and Production Scientific and Production Association, ArtLife LLC
Russian Federation, 634034, Nakhimova str., 8/2, Tomsk region, Tomsk city, Russia;Pavel Gennadievich Bylin
Scientific and Production Association "ArtLife"", Tomsk city, Russia
Email: bpg@artlife.ru
leading engineer for the implementation of new equipment and technologies Production Scientific and Production Association, ArtLife LLC
Russian Federation, 634034, Nakhimova str., 8/2, Tomsk region, Tomsk city, Russia;Sergey Emilievich Kondakov
Moscow State University M.V. Lomonosov Moscow, Russia
Email: ksekse@mail.ru
SPIN-code: 5951-3297
PhD (Chemical sciences), DSc (Pharmaceutical). Leading Researcher, Laboratory of Chemical Kinetics, Department of Chemical Kinetics
Russian Federation, 119234, 1 microdistrict Leninskie Gory, Moscow; Russia;Marina Yuzefovna Rozenshteyn
ImmunoHealth- RUS, Moscow
Email: marina.rozenshteyn@gmail.com
PhD (Medicine), MD, nutritionist, member of the American Association of Nutrition ANA, leading specialist “ImmunoHealth Rus” (Moscow)
Russian Federation, 123060, Moscow, st. Marshal Rybalko, 2.Arkady Zilmanovich Rozenshteyn
ImmunoHealth- RUS, Moscow
Email: arkrozen@gmail.com
DSc (Phys.-Math. Sci), Managing Partner of the ImmunoHealth Clinic
Russian Federation, 123060, Moscow, st. Marshal Rybalko, 2.Elizaveta Aleksandrovna Novikova
Federal State Budgetary Educational Institution of Higher Education "Siberian State Medical University" of the Ministry of Health of the Russian Federation, Tomsk, Russia
Author for correspondence.
Email: loginova.elizavetka@bk.ru
6th year student of the Faculty of Medicine, Siberian State Medical University
Russian Federation, 634055, Moskovsky tract, 2, Tomsk, Russia;References
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