Email this article INFLAMMATORY DISEASES OF THE MAXILLOFACIAL REGION AND ORAL CAVITY IN THE BACKGROUND OF IMMUNODEFICIENCIES
- Authors: Sarkisyan N.G.1,2, Kataeva N.N.1, Demidov S.D.3, Mkrtchyan I.G.1, Melikyan A.H.1, Оsipova I.M.1
-
Affiliations:
- Ural state medical university, Yekaterinburg, Russian Federation
- Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation
- Dental clinic "Denta OS", Yekaterinburg, Russian Federation
- Section: Immunological readings in Chelyabinsk
- Submitted: 07.03.2025
- Accepted: 25.05.2025
- URL: https://rusimmun.ru/jour/article/view/17111
- DOI: https://doi.org/10.46235/1028-7221-17111-IDO
- ID: 17111
Cite item
Full Text
Abstract
Abstract
Inflammatory diseases of the maxillofacial area and oral mucosa constitute the majority of the symptom complex found in patients with immunodeficiencies. The purpose – to assess the incidence of inflammatory diseases of the dental profile in patients with congenital immune deficiencies. Materials and methods. The study group of patients from the Sverdlovsk Regional Clinical Hospital No. 1 and the Regional Children's Clinical Hospital (Yekaterinburg) included 64 people with primary immunodeficiencies: combined immunodeficiencies, antibody defects, autoinflammatory disorders, phagocyte defects, immune dysregulation defects, complement defects, and an unverified diagnosis with signs of immunodeficiencies. Results. Lymphadenitis of the maxillofacial region, recurrent stomatitis, ulcers and cheilitis are characteristic of all the studied groups of patients, except for the group with complement defects. The diagnosis of candidiasis was identified in two classification groups: in "combined immunodeficiencies" (4.2% from the subgroup), "phagocyte defects" (50% from the subgroup). The same frequency of occurrence of maxillary sinusitis: in patients with "antibody defects" (46% from the subgroup), "autoinflammatory disorders" (13% from the subgroup), and abscesses, phlegmons of the maxillofacial region: "autoinflammatory disorders" (13% from the subgroup), "phagocyte defects" (10% from the subgroup). The highest percentage of inflammatory dental diseases, such as cheilitis (36% from the entire study group), stomatitis (33% from the entire study group), and maxillofacial lymphadenitis (31% from the entire study group), were found.
The maximum "set" of inflammatory diseases under study was diagnosed in patients with "anti-inflammatory disorders" and "phagocyte defects". At the same time, the largest number of people from these groups (60% and 70%, respectively) had recurrent stomatitis and ulcers. In the only patient diagnosed with "complement defects", inflammatory dental diseases were not detected.
Conclusions. Common dental manifestations in patients with congenital immune defects were identified: lymphadenitis of the maxillofacial region, cheilitis, stomatitis and ulcers. This will be useful for proper patient routing.
About the authors
Narine Grishaevna Sarkisyan
Ural state medical university, Yekaterinburg, Russian Federation;Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation
Email: narine_25@mail.ru
ORCID iD: 0000-0002-6175-5752
Doctor of Medical Sciences, professor of postgraduate department , Associate Professor of the Department of Therapeutic Dentistry and Propedeutics of Dental Diseases , Ural State Medical University, Yekaterinburg
Russian Federation, 620028, Russia, Yekaterinburg, Repina st., 3; 620078, Russia, Yekaterinburg, Pervomayskaya st., 106.Natalia Nikolaevna Kataeva
Ural state medical university, Yekaterinburg, Russian Federation
Email: kataeva.nn@mail.ru
ORCID iD: 0000-0002-2847-8810
PhD, associate professor, assistant professor of General Chemistry department
Russian Federation, 620026, Yekaterinburg, Dekabristov St., 32Sergey Dmitrievich Demidov
Dental clinic "Denta OS", Yekaterinburg, Russian Federation
Email: narine_25@mail.ru
dentist
Russian Federation, 620149, Russia, Ekaterinburg, st. Academician Bardin, 12.Inessa Garnikovna Mkrtchyan
Ural state medical university, Yekaterinburg, Russian Federation
Email: narine_25@mail.ru
ORCID iD: 0009-0007-8467-2654
physician of the medical prevention office
Russian Federation, 620142, Russia, Yekaterinburg, Belinsky st., 130Arsen Henrikovich Melikyan
Ural state medical university, Yekaterinburg, Russian Federation
Email: narine_25@mail.ru
Resident of the Department of Surgical Dentistry
Russian Federation, 620028, Russia, Yekaterinburg, Repina st., 3Izabella Mgerovna Оsipova
Ural state medical university, Yekaterinburg, Russian Federation
Author for correspondence.
Email: narine_25@mail.ru
Resident of the Department of Therapeutic Dentistry
Russian Federation, 620028, Russia, Yekaterinburg, Repina st., 3References
- Иванова О.Н., Бурцева Т.Е., Слободчикова М.П., Иванова И.С., Клинический случай селективного дефицита Ig A // Уральский медицинский журнал, 2020. № 10 (193). C. 46-48. Ivanova O.N., Burtseva T.E., Slobodchikova M.P., Ivanova I.S., Clinical case of selective deficiency Ig A. Uralskyi meditsinskyi zurnal = Ural Medical Journal, 2020, no. 10 (193), pp. 46-48. (In Russ.) https://doi.org: 10.25694/URMJ.2020.10.11
- Коваленко К.Е., Поликарпова И.И. Клинический случай врожденного герпетического менингоэнцефалита // Уральский медицинский журнал, 2020. № 04 (187). C. 140-145. Kovalenko K.E., Policarpova I.I., A clinical case of congenital herpetic meningoencephalitis.
- Uralskyi meditsinskyi zurnal = Ural Medical Journal, 2020, no. 4 (187), pp. 140-145. (In Russ.) https://doi.org: 10.25694/URMJ.2020.04.23
- Саркисян Н.Г., Тузанкина И.А., Катаева Н.Н., Меликян А.Г., Осипова И.М. Зубочелюстные аномалии при врожденных ошибках иммунитета // Российский иммунологический журнал, 2024. Т. 27, № 2. С. 217-222. Sarkisyan N.G., Tuzankina I.A., Kataeva N.N., Melikyan A.H., Оsipova I.M. Dental anomalies in congenital error of immunity. Rossiyskiy Immunologicheskiy Zhurnal = Russian Journal of Immunology, 2024, Vol. 27, no. 2, pp. 217-222. https://doi: 10.46235/1028-7221-16812-DAI
- Удилов, В.С., Сабитов А.У., Берсенева Т.В. Случай листериозного сепсиса у ВИЧ- инфицированного пациента // Уральский медицинский журнал, 2016. № 9(142). С. 130-133. Udilov V.S., Sabitov A.U., Berseneva T.V. Listerioses case of sepsis in HIV infected patient. Uralskyi meditsinskyi zurnal = Ural Medical Journal, 2016, no. 9 (142), pp. 130-133. (In Russ.) https://www.elibrary.ru/download/elibrary_27298652_60433785.pdf
- Уфимцева М.А., Сабитов А.У., Савченко Н.В., Ворошилина Е.С., Бочкарёв Ю.М., Гордон Е.О. Особенности микробиоты кожи у ВИЧ-инфицированных детей // Уральский медицинский журнал, 2020. № 04 (187). C. 94-97. Ufimtseva M.A., Sabitov A.U., Savchenko N.V., Podymova A.S., Voroshilina E.S., Bochkarev Yu.M., Gordon E.A., Skin microbiota in HIV-positive children. Uralskyi meditsinskyi zurnal = Ural Medical Journal, 2020, no. 4 (187), pp. 94-97. (In Russ.) https://doi.org: 10.25694/URMJ.2020.04.14
- Хайбуллина Р.Р., Гильмутдинова Л.Т., Герасимова Л.П. [и др.] Особенности местного иммунитета полости рта у пациентов с хроническим генерализованным пародонтитом и бруксизмом // Уральский медицинский журнал, 2017. № 11(155). С. 63-66. Khaybullina R.R., Gilmutdinova L.T., Gerasimova L.P., Victorov V.V., Makusheva N.V. Shamsiev M.R. Features of local immunity of the oral cavity in patients with chronic generalized periodontitis and bruxism. Uralskyi meditsinskyi zurnal = Ural Medical Journal, 2017, no. 11 (155), pp. 63-66. (In Russ.) https://www.elibrary.ru/download/elibrary_32362882_48126351.pdf
- Aluri J. et al. Clinical, immunological, and molecular findings in 57 patients with severe combined immunodeficiency (SCID) from India. Frontiers in immunology, 2019, V. 10. p. 23. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00023/full
- Barasa A. et al. Persistent oral candidiasis and disseminated BCGosis as manifestations of a possible inborn error of immunity. Current Allergy & Clinical Immunology, 2021, V. 34, no. 1, pp. 48-50. https://journals.co.za/doi/abs/10.10520/ejc-caci-v34-n1-a10
- Lanternier F. et al. Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both. Journal of Allergy and Clinical Immunology, 2015. V. 135, no. 6, pp. 1558-1568. https://doi.org/10.1016/j.jaci.2014.12.1930
- Okada S, Markle JG, Deenick EK, et al. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science (New York, NY), 2015, no. 349(6248), pp. 606-613. 10.1126/science.aaa4282' target='_blank'>https://doi: 10.1126/science.aaa4282
- Okada S, Puel A, Casanova J-L, Kobayashi M. Chronic mucocutaneous candidiasis disease associated with inborn errors of IL-17 immunity. Clinical & Translational Immunology. 2016, no. 5(12), p. 114. https:// doi: 10.1038/cti.2016.71.
- Scully C., Hodgson T., Lachmann H. Auto‐inflammatory syndromes and oral health. Oral diseases, 2008. V. 14, no. 8, pp. 690-699. https:// doi: 10.1111/j.1601-0825.2008.01484.x
- Wang X. et al. CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies. Journal of Allergy and Clinical Immunology, 2014. V. 133, no. 3, pp. 905-908. https:// doi: 10.1016/j.jaci.2013.09.033.
- Wang X. et al. Impaired specific antifungal immunity in CARD9-deficient patients with phaeohyphomycosis. Journal of Investigative Dermatology, 2018. V. 138, no. 3, pp. 607-617. https://doi.org/10.1016/j.jid.2017.10.009
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).