Email this article CHARACTERISTICS OF THE INTERFERON SYSTEM AND CELLULAR IMMUNITY OF THE CHILDREN WITH FIRST DIAGNOSED ACTIVE PULMONORY TUBERCULOSIS
- Authors: Sokolova T.F.1, Mordyk A.V.1, Shcheglova E.L.2, Sokol N.N.2, Aroyan A.R.1
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Affiliations:
- Omsk State Medical University
- V.P. Bisyarina City Children’s Clinical Hospital № 2
- Issue: Vol 22, No 2-1 (2019)
- Pages: 554-556
- Section: ORIGINAL ARTICLES
- Submitted: 18.05.2020
- Accepted: 18.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/214
- DOI: https://doi.org/10.31857/S102872210006971-3
- ID: 214
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Abstract
The article reveals the features of changes in the system of interferon and cellular immunity, structural and functional organization of the immune system by the number of correlations between its elements among the children with pulmonary tuberculosis. The article gives an analysis of secretion of IFNα and IFNγ, subpopulation composition of blood lymphocytes, communication in the immune system. It is stated that hypo secretion of IFNγ by lymphocytes in vitro with directed induction of cells is registered against the background of a decrease in the number of CD3+, CD4+, CD8+, CD16+, CD20+, HLA-DR+ lymphocytes, an increase in the number of connections between elements of the immune system with a decrease in its mobility.
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About the authors
T. F. Sokolova
Omsk State Medical University
Email: fake@neicon.ru
MD, Prof. at the Department of Pharmacology, Clinical Pharmacology,
Omsk
Russian FederationA. V. Mordyk
Omsk State Medical University
Email: fake@neicon.ru
MD, Professor, Head of the Department of Phthisiology and Phthisiosurgery,
Omsk
Russian FederationE. L. Shcheglova
V.P. Bisyarina City Children’s Clinical Hospital № 2
Author for correspondence.
Email: eleon_74@mail.ru
PhD, Doctor of clinical immunology laboratories,
Omsk
Russian FederationN. N. Sokol
V.P. Bisyarina City Children’s Clinical Hospital № 2
Email: fake@neicon.ru
The Head of the of Clinical Laboratory,
Omsk
Russian FederationA. R. Aroyan
Omsk State Medical University
Email: fake@neicon.ru
Assistant of the Sub-Department of Phthisiology and Phthisiosurgery,
Omsk
Russian FederationReferences
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- Правада Н. C., Серёгина В. А., Будрицкий А. М., Янченко В. В. Значение системы гамма-интерферона и туберкулинсвязывающих моноцитов у пациентов с распространёнными формами туберкулёза лёгких // Современные проблемы здравоохранения и медицинской статистики, 2018, № 2. С. 1–13.
- Писаренко М. С. Особенности секреции интерферона-гамма при лекарственно-устойчивом туберкулезе легких // Фундаментальные исследования, 2013. № 9, ч. 3. С. 444–447.
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