CONTENTS OF IL-18 AND MSR-1 IN CHILDREN WITH CONGENITAL CLEARANCE OF THE UPPER LIP AND SKY

A study was conducted to study the levels of pro-and anti-inflammatory cytokines (IL-2, IL-6, IL-18, MCP-1 and IL-4) in 46 children with cleft lip and palate, who were in the children’s republican hospital in Bukhara. All sick children underwent a comprehensive examination by specialists (surgeon, pediatrician, orthopedist, otolaryngologist, neuropsychiatrist) to identify abnormalities of a somatic nature and associated developmental defects. Studies on the level of cytokines showed that the synthesis of proinflammatory cytokines ‒ IL-6, IL-18, MCP-1 and anti-inflammatory cytokine IL-10 in children was significantly increased, while the level of IL-2 was slightly lower than the control values. Noted changes in the state of cytokine status can be qualified as a secondary immunodeficiency state, requiring immunomodulatory measures.