STING ACTIVATION IN T CELLS LEADS TO UPR AND CELL DEATH

V. V. Ilyukha; Илюха В. В.; B. Larkin; Ларкин Б.; A. P. Prohorova; Прохорова А. П.; A. N. Poltorak; Полторак А. Н.

doi:10.31857/S102872210006699-3

STING ACTIVATION IN T CELLS LEADS TO UPR AND CELL DEATH

Authors: Ilyukha V.V.¹, Larkin B.², Prohorova A.P.¹, Poltorak A.N.¹^,2
Affiliations:
1. Petrozavodsk State University
2. Department of Immunology, Tufts University Immunology Program, Boston
Issue: Vol 22, No 2-2 (2019)
Pages: 784-785
Section: ORIGINAL ARTICLES
Submitted: 03.06.2020
Accepted: 03.06.2020
Published: 15.07.2019
URL: https://rusimmun.ru/jour/article/view/300
DOI: https://doi.org/10.31857/S102872210006699-3
ID: 300

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Abstract

Despite well-studied role of the adapter STING in the cell response to cytosolic DNA, its contribution to the activation of programmed cell death was not considered at the proper level. In this study was shown that activation of STING in T cells leads to production of typeI interferons, upregulation expression levels of the interferon-stimulating gene group (ISG), as well as cell death. It is also shown that cell death is mediated by UPR (Unfolded Protein Response).