THE MODEL OF PSORIASIFORM DERMATITIS IN MICE INDUCED BY INTRADERMAL ADMINISTRATION OF RECOMBINANT HUMAN IL-36γ

A. A. Kolobov; Колобов А. А.; T. A. Sazonova; Сазонова Т. А.; G. V. Alexandrov; Александров Г. В.; A. V. Petrov; Петров А. В.

doi:10.31857/S102872210006690-4

THE MODEL OF PSORIASIFORM DERMATITIS IN MICE INDUCED BY INTRADERMAL ADMINISTRATION OF RECOMBINANT HUMAN IL-36γ

Authors: Kolobov A.A.¹, Sazonova T.A.¹, Alexandrov G.V.¹, Petrov A.V.¹
Affiliations:
1. State Research Institute of Highly Pure Biopreparations
Issue: Vol 22, No 2-2 (2019)
Pages: 807-809
Section: ORIGINAL ARTICLES
Submitted: 04.06.2020
Accepted: 04.06.2020
Published: 15.07.2019
URL: https://rusimmun.ru/jour/article/view/308
DOI: https://doi.org/10.31857/S102872210006690-4
ID: 308

Cite item

Full Text

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

We developed and characterized the model of psoriasiform dermatitis in mice induced by induced by intradermal administration of recombinant human IL-36γ. Induced skin lesions resemble human psoriasis in means of both macroscopic (PASI) and microscopic features (acanthosis, parakeratosis, dermal leucocyte infiltration). This model can be used for anti-psoriatic drugs efficiency research.