THE ROLE OF B1 AND B2 LYMPHOCYTES IN THE FORMATION OF DIFFERENT VARIANTS OF RHEUMATOID ARTHRITIS

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Abstract

The results of the phenotypic characteristics of B1 and B2 lymphocytes of patients with seropositive (51 people) and seronegative (41 people) variants of the course of articular form of rheumatoid arthritis are presented. An increase in the content of B1 lymphocytes in both seronegative and seropositive variants was shown. A distinctive feature of B2 lymphocytes in the seropositive compared with the seronegative option is to enhance the activation processes and decrease the intensity of apoptosis with the progression of the autoimmune process.

About the authors

L. P. Sizyakina

Rostov State Medical University

Author for correspondence.
Email: msiziakina@mail.ru

MD, PhD, Head of the Department of Clinical Immunology and Allergology, Director of the Institute of Clinical Immunology,

Rostov-on-Don

Russian Federation

M. V. Kharitonova

Rostov State Medical University

Email: fake@neicon.ru

Post-Graduate Student of the Department of Clinical Immunology and Allergology,

Rostov-on-Don

Russian Federation

References

  1. Насонов Е. Л., Александрова Е. Н., Новиков А. А. Аутоиммунные ревматические заболевания ‒ проблемы иммунопатологии и персонифицированной терапии // Вестн. РАМН. – 2015. – Т. 70, № 2. – С. 169–182.
  2. Bugatti S. B cell autoimmunity and bone damage in rheumatoid arthritis / S. Bugatti, L. Bogliolo, C. Montecucco, A. Manzo // Reumatismo. – 2016. – Vol. 68, N3. – P. 117–125.
  3. Сизякина Л. П., Харитонова М. В. Характеристика В2-лимфоцитов у пациентов с серонегативным ревматоидным артритом суставной формы // Иммунология. – 2018. – Т. 39, № 2–3. – С. 134–137.

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Copyright (c) 2019 Sizyakina L.P., Kharitonova M.V.

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