INFLUENCE OF ALPHA-FETOPROTEIN ON CYTOKIN PROFILE OF ACTIVATED T-HELPERS

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Abstract

The effect of alpha-fetoprotein (AFP) on the pro-infl ammatory cytokine profi le of activated T-helpers, polarazed in phenotyp of Th17. It was found that AFP did not affect the level of IL-4, IL-5, IL-7, IL-8, IL-10, IL-17, MCP-1, MIP-1α, TNF-α, but in high concentrations (50, 100 IU/ml) increased IL-2 production by activated T-helper cells. At the same time, AFP in high concentration (100 IU/ml) suppressed the synthesis of IFN-γ, and in low (10 IU /ml) synthesis of G-CSF and GM-CSF. Thus, new aspects of the AFP action regarding the regulation of the cytokine network of Th17 are demonstrated.

About the authors

S. A. Zamorina

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Author for correspondence.
Email: mantissa7@mail.ru

Ph.D., MD (Biology), leading researcher, laboratory of ecological immunology, «Institute of ecology and genetics of microorganisms UB RAS»,

professor of the department of microbiology and immunology of the Perm State University’s Faculty of Biology,

Perm

Russian Federation

L. S. Litvinova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

PhD, MD (Medicine), Head, Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

N. M. Todosenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

PhD (Biology), Researcher, Basic Laboratory of Immunology and Cell Biotechnologies, 

Kaliningrad

Russian Federation

V. P. Timganova

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D. (Biology), junior researcher, laboratory of ecological immunology,

Perm

Russian Federation

M. S. Bochkova

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D. (Biology), researcher, laboratory of ecological immunology,

 

Russian Federation

K. Y. Shardina

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

researcher, laboratory of ecological immunology,

 

Russian Federation

P. V. Khramtsov

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D. (Biology), researcher, laboratory of ecological immunology, «Institute of ecology and genetics of microorganisms UB RAS»,

assistant professor of the department of microbiology and immunology of the Perm State University’s Faculty of Biology,

Perm

Russian Federation

M. B. Raev

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D., MD (Biology), Leading Researcher, Laboratory of Ecological Immunology, «Institute of ecology and genetics of microorganisms UB RAS»,

professor of the department of microbiology and immunology of the Perm State University’s Faculty of Biology,

Perm

Russian Federation

V. A. Chereshnev

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Academician of the Russian Academy of Sciences, MD, Chief Researcher,

Perm

Russian Federation

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Copyright (c) 2019 Zamorina S.A., Litvinova L.S., Todosenko N.M., Timganova V.P., Bochkova M.S., Shardina K.Y., Khramtsov P.V., Raev M.B., Chereshnev V.A.

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