INFLUENCE OF MURAMYL DIPEPTIDE DERIVATE (GMDP-A) ON NOD-2 EXPRESSED TUMOUR CELL LINES

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  • Authors: Gaponov A.M.1,2, Yakushenko E.V.1, Tutelyan A.V.3, Kozlov I.G.1
  • Affiliations:
    1. D. Rogachev National Medical Research Center for Pediatrics Hematology, Oncology and Immunology
    2. Federal Scientific and Clinical Center for Reanimatology and Rehabilitation
    3. Federal Budget Institution of Science “Central Research Institute of Epidemiology” of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance
  • Issue: Vol 21, No 2 (2018)
  • Pages: 128-140
  • Section: ORIGINAL ARTICLES
  • Submitted: 15.04.2020
  • Accepted: 15.04.2020
  • Published: 15.04.2018
  • URL: https://rusimmun.ru/jour/article/view/66
  • ID: 66

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Abstract

Muramyl dipeptides (MDP) are the multiple repeating structural unit of a cell wall peptidoglycan of all the bacteria, which possess the ability to interact with cytoplasmic receptors of the NOD family in human cells and induce activation of the innate immunity. This makes them the promising compounds for the development of drugs for immunomodulating therapy and in particular for biotherapy of tumors. However, there exists data on the expression of MDP targeting NOD receptors in tumor cells and association of some types of cancer with different polymorphic variants of these receptors. In this connection, the purpose of the reported study was to investigate the effect of MDP synthetic analogue, i. e. GMDP-A on the proliferative capacity of NOD2-expressing tumor cell lines of various origin, and the effect of the combined use of GMDP-A with cisplatina. As a result of the performed studies, it has been demonstrated that GMDP-A (at the doses of 1, 5, 10, 20 and 40 μg/ml) itself and GMDP-A in combination with cisplatina exerted differently directed effects.

About the authors

A. M. Gaponov

D. Rogachev National Medical Research Center for Pediatrics Hematology, Oncology and Immunology; Federal Scientific and Clinical Center for Reanimatology and Rehabilitation

Email: fake@neicon.ru

PhD, Head of the Laboratory of Infection Immunology; Leading Researcher, Laboratory of Molecular Mechanisms of Critical States

Moscow

Russian Federation

E. V. Yakushenko

D. Rogachev National Medical Research Center for Pediatrics Hematology, Oncology and Immunology

Email: fake@neicon.ru

DrSci, Leading Researcher, Experimental and Clinical Pharmacology Department

Moscow

Russian Federation

A. V. Tutelyan

Federal Budget Institution of Science “Central Research Institute of Epidemiology” of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance

Email: fake@neicon.ru
ORCID iD: 0000-0002-2706-6689

DrSci, Professor, Corresponding member of the Russian Academy of Sciences, Head of Laboratory Associated Infections Health Care

eLibrary SPIN: 8150–2230

Moscow Russian Federation

I. G. Kozlov

D. Rogachev National Medical Research Center for Pediatrics Hematology, Oncology and Immunology

Author for correspondence.
Email: immunopharmacology@yandex.ru

DrSci, professor, Chief of Experimental and Clinical Pharmacology Department

117997 Moscow, Samory Mashela str. 1

Russian Federation

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