HEPATITIS C VIRUS COINFECTION DISTURBS NAIVE CD4+ T-CELL HOMEOSTASIS IN HIV-INFECTED PATIENTS

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Abstract

It has been established that during HIV/HCV coinfection a naive СD4+ T-cell deficiency and a disruption of the cell transition between the two subsets: СD4+ recent thymic migrants and the mature СD4+ naive T cells, is developed. In HIV/HCV coinfection, unlike HIV monoinfection, the dependence of homeostatic proliferation on T-cell count is disturbed.

About the authors

K. V. Shmagel

Institute of Ecology and Genetics of Microorganisms, Perm, Russia; Perm Regional Center for Protection against AIDS and Infectious Diseases

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

E. V. Saidakova

Institute of Ecology and Genetics of Microorganisms, Perm, Russia; Perm Regional Center for Protection against AIDS and Infectious Diseases

Email: noemail@neicon.ru
Russian Federation

L. B. Korolevskaya

Institute of Ecology and Genetics of Microorganisms, Perm, Russia; Perm Regional Center for Protection against AIDS and Infectious Diseases

Email: noemail@neicon.ru
Russian Federation

N. G. Shmagel

Institute of Ecology and Genetics of Microorganisms, Perm, Russia; Perm Regional Center for Protection against AIDS and Infectious Diseases

Email: noemail@neicon.ru
Russian Federation

V. A. Chereshnev

Institute of Ecology and Genetics of Microorganisms, Perm, Russia; Perm Regional Center for Protection against AIDS and Infectious Diseases

Email: noemail@neicon.ru
Russian Federation

References

  1. Rhodes T., Platt L., Judd A., Mikhailova L. A., Sarang A., et al. Hepatitis C virus infection, HIV coinfection, and associated risk among injecting drug users in Togliatti, Russia. Int J STD AIDS 2005, 16, 749-754.
  2. Bajaria S. H., Webb G., Cloyd M. and Kirschner D. Dynamics of naive and memory СD4+ T-lympho-cytes in HIV-1 disease progression. J Acquir Immune Defic Syndr 2002, 30, 41-58.
  3. Kilpatrick R. D., Rickabaugh T., Hultin L. E., Hul-tin P., Hausner M. A., et al. Homeostasis of the naive СD4(+) T cell compartment, during aging. Journal of Immunology 2008, 180, 1499-1507.
  4. Fry T. J., Connick E., Falloon J., Lederman M. M., Liewehr D. J., et al. A potential role for interleukin-7 in T-cell homeostasis. Blood 2001, 97, 2983-2990.

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Copyright (c) 2017 Shmagel K.V., Saidakova E.V., Korolevskaya L.B., Shmagel N.G., Chereshnev V.A.

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