Email this article Immune biomarkers of in-stent restenosis after percutaneous coronary interventions in myocardial infarction and stable angina patients
- Authors: Grachev N..1, Semenikhin A..1, Turmova E..1, Rublev V..2, Nazarenko S..2, Anohina N..2
-
Affiliations:
- Pacific State Medical University
- Primorye Regional Clinical Hospital № 1
- Issue: Vol 21, No 3 (2018)
- Pages: 255-260
- Section: ORIGINAL ARTICLES
- Submitted: 22.10.2020
- Published: 15.07.2018
- URL: https://rusimmun.ru/jour/article/view/875
- DOI: https://doi.org/10.31857/S102872210002391-5
- ID: 875
Cite item
Full Text
Abstract
The study was aimed to assess the prognostic role of infl ammation biomarkers to evaluate the risk for restenosis in myocardial infarction and stable angina patients undergoing percutaneous coronary intervention. The blood samples were tested immediately before and 7 days after percutaneous coronary intervention for IFN-γ, IL-6, IL-8, IL-17, TNF-α, TNF-β, TGF-β1 and TGF-β2. The key predictors of restenosis after percutaneous coronary intervention during one year were abnormal rates of IFN-γ pre-PCI (OR=5,21) and 7 days after (OR=3,84), IL-6 pre-PCI (OR=1,59), IL-8 pre-PCI (OR=1,73), IL-17 pre- PCI (OR=3,07) and 7 days after (OR=2,34), TNF-α pre-PCI (OR=1,88), TNF-β pre-PCI (OR=1,98) and growth factors: TGF-β1 7 days after PCI (OR=1,82) and TGF-β2 7 days after PCI (OR=2,04).
About the authors
N. . Grachev
Pacific State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. . Semenikhin
Pacific State Medical University
Email: noemail@neicon.ru
Russian Federation
E. . Turmova
Pacific State Medical University
Email: noemail@neicon.ru
Russian Federation
V. . Rublev
Primorye Regional Clinical Hospital № 1
Email: noemail@neicon.ru
Russian Federation
S. . Nazarenko
Primorye Regional Clinical Hospital № 1
Email: noemail@neicon.ru
Russian Federation
N. . Anohina
Primorye Regional Clinical Hospital № 1
Email: noemail@neicon.ru
Russian Federation
References
- Силаев А. А., Турмова Е. П., Маркелова Е. В. Анализ эффективности цитокинотерапии в послеоперационном периоде у пациентов с коронарным атеросклерозом. Тихоокеанский медицинский журнал 2013, 3, 18–21.
- Toutouzas K., Colombo A., Stefanadis C. Infl ammation and restenosis after percutaneous coronary interventions. European heart journal 2004, 25(19), 1679–1687.
- Byrne R. A., Joner M., Kastrati A. Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Grüntzig Lecture ESC2014. European heart journal 2015, 36(47), 3320–3331.
- Okamoto E. I., Couse T., De Leon H., et al. Perivascular infl ammation after balloon angioplasty of porcine coronary arteries. Circulation 2001, 104(18), 2228–2235.
- Chrobak I., Lenna S., Stawski L., Trojanowska M. Interferon- γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2. Journal of cellular physiology 2013, 228(8), 1774–1783.
- Szkodzinski J., Blazelonis A., Wilczek K., et al. The role of interleukin-6 and transforming growth factor-β1 in predicting restenosis within stented infarct-related artery. International journal of immunopathology and pharmacology 2009, 22(2), 493–500.
- Eyüboğlu M. In stent restenosis after percutaneous coronary intervention. Anatolian journal of cardiology 2016, 16(1), 73.
- heng G., Wei L., Xiurong W., Xiangzhen L., Shiguang Z., Songbin F. IL-17 stimulates migration of carotid artery vascular smooth muscle cells in an MMP-9 dependent manner via p38 MAPK and ERK1/2-dependent NFkappaB and AP-1 activation. Cellular and molecular neurobiology 2009, 29(8), 1161–1168.
- Monraats P. S., Pires N. M., Schepers A., et al. Tumor necrosis factor-alpha plays an important role in restenosis development. FASEB journal: offi cial publication of the Federation of American Societies for Experimental Biology 2005, 19(14), 1998–2004.
- Koch W., Tiroch K., von Beckerath N., Schömig A., Kastrati A. Tumor necrosis factor-α, lymphotoxin-α, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting. Cytokine 2003, 24(4), 161–171.
- Zhao W., Wang C., Liu R., et al. Eff ect of TGF-β1 on the migration and recruitment of mesenchymal stem cells after vascular balloon injury: involvement of matrix metalloproteinase-14. Scientifi c reports 2016, 6, 21176.
- Joviliano E. E., Piccinato C. E., Dellalibera-Joviliano R., Moriya T., Évora P. R. Infl ammatory markers and restenosis in peripheral percutaneous angioplasty with intravascular stenting: current concepts. Annals of vascular surgery 2011, 25(6), 846–855.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).