RESULTS OF THE PRE-CLINICAL STUDY OF A NEW IMMUNOCORRECTOR OF FLORAL ORIGIN
- Authors: Dutova S.V.1, Karpova M.R.2
-
Affiliations:
- Khakass state University named after N. F. Katanov
- Siberian State Medical University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 239-241
- Section: ORIGINAL ARTICLES
- Submitted: 16.04.2020
- Accepted: 16.04.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/101
- DOI: https://doi.org/10.31857/S102872210006587-0
- ID: 101
Cite item
Full Text
Abstract
The article presents the results of the preclinical study of the immunocorrective properties of the total ethanol extract from the raw material of the medicinal plant of the traditional medicine of Siberia – Coluria geoides (Pall.) Ledeb.), Rosaceae. The eff ect of extract on the phagocytic activity of peripheral blood neutrophils and the main indicators of the humoral immune response (the number of antibody-forming cells of the spleen and the synthesis of anti-erythrocyte antibodies) were evaluated on a model of experimental immunodefi ciency in inbred mice. Extract from raw materials C. geoides showed a pronounced immunomodulatory eff ect, in some parameters superior to the eff ect of offi cinal tincture of Echinacea.
About the authors
S. V. Dutova
Khakass state University named after N. F. Katanov
Author for correspondence.
Email: coluria@mail.ru
DPhs, associate Professor, acting head of the Department of fundamental medicine and hygiene of Medical, psychological and social Institute,
Abakan
Russian FederationM. R. Karpova
Siberian State Medical University
Email: fake@neicon.ru
DM, Professor, head of the Department of Microbiology and Virology,
Tomsk
Russian FederationReferences
- Караулов А. В., Калюжин О. В. Иммунотерапия инфекционных болезней: проблемы и перспективы. Терапевтический архив. 2013, 85 (11), 100–108.
- Ревякина В. А. Перспективы использования растительных иммуномодуляторов в профилактике и терапии респираторных инфекций у детей. Инфекционные болезни, 2013, 11(1), 93–96.
- Хобракова В. Б., Цыренова Д. З., Торопова А. А., Оленников Д. Н. Иммуномодулирующая и антиоксидантная активность сухого экстракта Phlomoides tuberosa (L.) MOENCH. Экспериментальная и клиническая фармакология, 2017, 80 (3), 26–30.
- Руководство по проведению доклинических исследований лекарственных средств. Часть первая. Под ред. А. Н. Миронова. М.: Гриф и К, 2012, 944 с.
- Хобракова В. Б., Николаев С. М. Растительные иммуномодуляторы в коррекции иммунодефицитов. Российский аллергологический журнал, 2008, 1, 324–325.