Email this article CATALASE ACTIVITY OF CATALYTIC ANTIBODIES IN SCHIZOPHRENIA
- Authors: Ermakov E.A.1,2, Smirnova L.P.3, Krotenko N.M.3, Semke A.V.3, Buneva V.N.2, Nevinsky G.A.2
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Affiliations:
- Novosibirsk State University
- Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
- Mental Health Research Institute
- Issue: Vol 22, No 2-1 (2019)
- Pages: 242-244
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/102
- DOI: https://doi.org/10.31857/S102872210006588-1
- ID: 102
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Abstract
In this work, the ability of catalytic antibodies (abzymes) in patients with schizophrenia and healthy donors to catalyze the decomposition of hydrogen peroxide was investigated. The polyclonal IgG in patients with schizophrenia and healthy donors was found to have catalase activity, and the activity of patient’s IgG was 1.7 times higher. The heterogeneity of abzymes with catalase activity by affi nity to metal ions, pH optimum, kinetic parameters is shown. A possible antioxidant function of catalytic antibodies with catalase activity is discussed.
About the authors
E. A. Ermakov
Novosibirsk State University;Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Author for correspondence.
Email: evgeny_ermakov@mail.ru
Assistant of Department of Molecular Biology and Biotechnology, Novosibirsk State University, Novosibirsk, Russia; Senior Laboratory Assistant, Laboratory of Repair Enzymes,
Novosibirsk
Russian FederationL. P. Smirnova
Mental Health Research Institute
Email: fake@neicon.ru
PhD, Senior Researcher, Laboratory of Molecular Genetics and Biochemistry,
Tomsk
Russian FederationN. M. Krotenko
Mental Health Research Institute
Email: fake@neicon.ru
Ph.D., Senior Researcher, Laboratory of Molecular Genetics and Biochemistry,
Tomsk
Russian FederationA. V. Semke
Mental Health Research Institute
Email: fake@neicon.ru
MD, Professor, Deputy Director for Scientifi c and Medical Work, Head of the Department of Endogenous Disorders,
Tomsk
Russian FederationV. N. Buneva
Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Email: fake@neicon.ru
Dr. Sc., prof., Chief Researcher of the Laboratory of Repair Enzymes,
Novosibirsk
Russian FederationG. A. Nevinsky
Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Email: fake@neicon.ru
Dr. Sc., prof., Head of the Laboratory of Repair Enzymes,
Novosibirsk
Russian FederationReferences
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- Steullet P., Cabungcal J.H., Monin A., Dwir D., O’Donnell P., Cuenod M., Do K. Q. Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? Schizophrenia research. 2016, 176(1), 41–51.
- Nevinsky G. A., Buneva V. N. Natural catalytic antibodies in norm, autoimmune, viral, and bacterial diseases. The Scientific World Journal, 2010, 10, 1203–1233.
- Ермаков Е. А., Толмачева А. С., Смирнова Л. П., Иванова С. А., Бунева В. Н., Невинский Г. А. Особенности окислительно-восстановительных, амилазной и АТРазной активностей IgG антител из крови больных шизофренией. Российский иммунологический журнал, 2017, 11(4), 627–640.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).