THE RELATIONSHIP OF POSTOPERATIVE COGNITIVE DYSFUNCTION WITH THE LEVEL OF METALLOPROTEINASE-2 AND INTERLEUKIN-17 AND TRANSFORMING GROWTH FACTOR β2

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Abstract

30 patients after CABG were examined. The patients were divided into two groups on the basis of MoCa test results. Outcome monitoring of MMP-2, IL-17, TGFβ2 level in the blood serum was carried out 4 times by means of microparticle enzyme immunoassay before the surgery, after the surgery, as well as on the 1st and 7th day following the surgery. In patients with PCD the higher level of IL-17 was distinguished. Alongside with the low levels of GFβ2 and MMP-2 after the surgery, which is determined by a more vivid proinflammatory response and the insuffi ciency of the proinflammatory reaction.

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About the authors

A. A. Zenina

FSBEU HPE «Pacific State Medical University» of the Ministry of Health Care of the Russia

Author for correspondence.
Email: zenina.aa@dvfu.ru

post-graduate student of the department of Normal and Pathological physiology,

Vladivostok

Russian Federation

D. F. Bekerova

FSBEU HPE «Pacific State Medical University» of the Ministry of Health Care of the Russia

Email: fake@neicon.ru

student,

Vladivostok

 

Russian Federation

Aleksandra I

FSBEU HPE «Pacific State Medical University» of the Ministry of Health Care of the Russia

Email: fake@neicon.ru

student,

Vladivostok

Russian Federation

L. D. Markina

FSBEU HPE «Pacific State Medical University» of the Ministry of Health Care of the Russia

Email: fake@neicon.ru

DMS, professor of the department of Normal and pathological physiology,

Vladivostok

Russian Federation

References

  1. Новицкая-Усенко Л. В. ПКД в практике врачаанестезиолога // Медицина неотложных состояний. –2017. –№ 4(83). – С. 9–15.
  2. Левин С. Г., Годухин О. В. Модулирующее действие цитокинов на механизмы синаптической пластичности в мозге обзор // Биохимия. –2017. – Т. 82. –№ 3. – Р. 397–409.
  3. Просекова Е. В., Турянская А. И., Сабыныч В. А. Оценка системы Il-17 у детей с аллергической бронхиальной астмой // ТМЖ –2018. –№ 4. – С. 29–31.
  4. Симбирцев А. С. Цитокины в патогенезе и лечении заболеваний человека. СПб.: Фолиант, 2018. 512 с.

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Copyright (c) 2019 Zenina A.A., Bekerova D.F., I A., Markina L.D.

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