GLYCOPATHOLOGY OF FETOPLACENTAL-MATERNAL SYSTEM IN THE «GREAT OBSTETRICAL SYNDROMES» ASSOCIATED WITH DISORDERS OF DEEP PLACENTATION

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Abstract

The features of the glycophenotype of the placenta, the repertoire and the content of anti-glycan antibodies of the blood were studied using lectin histochemistry and glycochip in preeclampsia (PE) and fetal growth restriction (FGR), which indicate the development of glycopathology in the fetoplacentalmathernal system and the different pathogenesis of early and late PE and FGR.

About the authors

M. M. Ziganshina

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: mmz@mail.ru

PhD, senior scientist of laboratory of clinical immunology,

Moscow

Russian Federation

N. V. Shilova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;
Federal Budget Institution of Science «M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry»;
Semiotik LLC

Email: fake@neicon.ru

senior scientist of laboratory of clinical immunology;

senior scientist of Department of chemical biology of glycans and lipids;

chief microchip specialist,

Moscow

Russian Federation

G. V. Kulikova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

PhD, senior scientist of department of anatomic pathology,

Moscow

Russian Federation

N. R. Khasbiullina

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;
Federal Budget Institution of Science « N. D. Zelinsky Institute of Organic Chemistry»;
Semiotik LLC

Email: fake@neicon.ru

staff scientist of laboratory of clinical immunology';

junior scientist of laboratory of carbohydrate chemistry Zelinsky Institute of Organic Chemistry;

microchip specialist,

Moscow

Russian Federation

A. I. Shchegolev

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

MD, prof., head of the departmenth of anatomic pathology,

Moscow

Russian Federation

A. Yu. Nokel

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;
Semiotik LLC

Email: fake@neicon.ru

PhD, senior scientist of laboratory of clinical immunology;

chief engineer,

Moscow

Russian Federation

E. L. Dolgopolova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

2nd year resident,

Moscow

Russian Federation

N. V. Bovin

Federal Budget Institution of Science «M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry»

Email: fake@neicon.ru

Dr. habil., professor, chief of Department of chemical biology of glycans and lipids,

Moscow

Russian Federation

References

  1. Blixt O., Head S., Mondala T., Scanlan C., Hufl ejt M. E., Alvarez R., Bryan M. C., Fazio F., Calarese D., Stevens J., Razi N., Stevens D. J., Skehel J.J., van Die I., Burton D.R., Wilson I.A., Cummings R., Bovin N., Wong C.H., Paulson J.C. Printed covalent glycan array for ligand profi ling of diverse glycan binding proteins. Proc Natl Acad Sci. 2004, 7;101(49):17033–8.
  2. Huflejt M.E., Vuskovic M., Vasiliu D., Xu H., Obukhova P., Shilova N., Tuzikov A., Galanina O., Arun B., Lu K., Bovin N. Anti-carbohydrate antibodies of normal sera: findings, surprises and challenges. Mol. Immunol. 2009, 46(15): 3037–49.

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Copyright (c) 2019 Ziganshina M.M., Shilova N.V., Kulikova G.V., Khasbiullina N.R., Shchegolev A.I., Nokel A.Y., Dolgopolova E.L., Bovin N.V.

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