A METABOLIC SPECTRUM OF THE GUT MICROBIOTA FOR THE PATIENTS WITH ASTHMA

A content and profiles of short chain fatty acids (SCFAs) were studied into the feces of the patients with bronchial asthma and healthy persons too. A decrease of the absolute content and profiles changing of the short chain fatty acids (SCFAs) were detected after the lactic acid fl ora metabolic activity decreasing of (bifidobacteria and lactobacilli). An increasing of these parameters (isoCn and isoCn / Сn) indicates on a destruction of the epithelial layer of the intestinal wall. The anaerobic index values have refl ected the redox potential of the intraluminal environment. As it was detected the anaerobic index changing could lead to the growth of the facultative aerobic and residual (conditionally pathogenic) aerobic microfl ora. The revealed SCFA’s changes give evidence about the pronounced disorders in the intestinal biotope’s microbiocenosis and this fact could be considered as one of the reasons of the bronchial asthma development.