IMMUNOPATOGENIC FEATURES OF HEMORRHAGIC FEVER WITH RENAL SYNDROME IN THE DYNAMICS OF THE INFECTIOUS PROCESS

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Abstract

Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic viral infection, clinically manifested by a hemorrhagic syndrome and acute renal failure. The aim of the work was to study the dynamics of lymphocytes of innate and adaptive immune response in patients with HFRS during feverish, oliguric, polyuric periods and in reconvalescence. There were some features of the immunopathogenesis of HFRS: a high content in blood of regulatory T-lymphocytes, the prevalence in the initial stages of the disease reaction of natural killer cells, the delay of the development of adaptive cellular immune response involving cytotoxic T-lymphocytes.

About the authors

M. F. Ivanov

Samara State Medical University

Author for correspondence.
Email: fake@neicon.ru

PhD, associate professor of the Department of General and Clinical Microbiology, Immunology and Allergology,

Moscow

Russian Federation

A. V. Zhestkov

Samara State Medical University

Email: fake@neicon.ru

MD, professor, Head of the Department of General and Clinical Microbiology, Immunology and Allergology,

Moscow

Russian Federation

A. A. Suzdalcev

Samara State Medical University

Email: fake@neicon.ru

MD, Professor, Head of the Department of Infectious Diseases and Epidemiology,

Moscow

Russian Federation

L. L. Popova

Samara State Medical University

Email: fake@neicon.ru

MD, Professor of the Department of infectious diseases and Epidemiology,

Moscow

Russian Federation

I. P. Balmasova

A.I.Evdokimov Moscow Univercity of Medcine & Dentistry;
Peoples ‘ Friendship University of Russia

Email: iri.balm@mail.ru

MD, Professor, Head of the Laboratory of the Pathogenesis and Treatment of Infectious Diseases;

Professor of Allergology and Immunology Department of Medical Institute,

Moscow

Russian Federation

References

  1. Ткаченко Е. А., Дзагурова Т. К., Бернштейн А. Д., Коротина Н. А., Окулова Н. М., Мутных Е. С., Иванов А. П., Ишмухаметов А. А., Юничева Ю. В., Пиликова О. М., Морозов В. Г., Транквилевский Д. В., Городин В. Н., Бахтина В. А., Соцкова С. Е. Геморрагическая лихорадка с почечным синдромом (история, проблемы и перспективы изучения). Эпидемиология и вакцинопрофилактика. 2016, 15(3): 23–34.
  2. Сиротин Б. З. Вопросы классификации геморрагической лихорадки с почечным синдромом. Клиническая медицина. 1977, 55(2): 117–123.
  3. Jiang H, Du H, Wang LM, Wang PZ, Bai XF. Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. Front Cell Infect Microbiol. 2016; 6: 1–11.
  4. Scholz S., Baharom F., Rankin G., Maleki K. T., Gupta S., Vangeti S., Pourazar J., Discacciati A., Hoij er J., Bottai M., Bjorkstrom N. K., Rasmuson J., Evander M., Blomberg A., Ljunggren H. G., Klingstrom J., Ahlm C., Smed-Sorensen A. Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways. PLoS Pathol. 2017, 13(6): e1006462.
  5. Zheng X, Ye C, Zhao J, Bian P, Zhang Y, Jia Z. Alterations and clinical signifecance of exosome-containing innate immunity related lncRNAs in patients of hemorrhagic fever with renal syndrome. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016, 32(11):1522–1526.

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Copyright (c) 2019 Ivanov M.F., Zhestkov A.V., Suzdalcev A.A., Popova L.L., Balmasova I.P.

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