Email this article DIAGNOSTIC VALUE OF IMMUNOLOGICAL MARKERS OF ALLERGIC BRONCHOPULMONARY ASPERGILOSIS IN PATIENTS WITH ASTHMA
- Authors: Kozlova Y.I.1, Frolova E.V.1, Uchevatkina A.E.1, Filippova L.V.1, Vasileva N.V.1, Klimko N.N.1
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Affiliations:
- North-Western State Medical University named after I. I. Mechnikov
- Issue: Vol 22, No 2-1 (2019)
- Pages: 311-313
- Section: ORIGINAL ARTICLES
- Submitted: 27.04.2020
- Accepted: 27.04.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/132
- DOI: https://doi.org/10.31857/S102872210006611-7
- ID: 132
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Abstract
Allergic bronchopulmonary aspergillosis (ABPA) is a severe lung disease caused by hypersensitivity to Aspergillus spp. The search for new diagnostic markers is essential for early detection of the disease in patients at risk and identifying eff ective treatment strategies. 21 patients with ABPA, 37 patients with asthma and 16 healthy subjects were examined. The content of thymic stromal lymphopoietin (TSLP), thymus-associated regulatory chemokine (TARC), IL-8, eosinophil count, total IgE levels and specifi c IgE to Aspergillus fumigatus were determined in serum by ELISA. The positive correlation of the TARC level with the indicators of total IgE, sIgE to Aspergillus fumigatus, the number of eosinophils and the negative correlation relationship with the FEV1 value confi rms the important diagnostic value of this pro-infl ammatory chemokine in patients with ABPA.
About the authors
Y. I. Kozlova
North-Western State Medical University named after I. I. Mechnikov
Author for correspondence.
Email: kozlova510@mail.ru
PhD, Assistant - Professor of Department of Clinical Mycology, Allergology and Immunology,
Saint-Petersburg
Russian FederationE. V. Frolova
North-Western State Medical University named after I. I. Mechnikov
Email: fake@neicon.ru
PhD, Head of the Laboratory of Immunology and Allergology Kashkin Research Institute of Medical Mycology,
Saint-Petersburg
Russian FederationA. E. Uchevatkina
North-Western State Medical University named after I. I. Mechnikov
Email: fake@neicon.ru
PhD, Senior Researcher of Immunology and Allergology Kashkin Research Institute of Medical Mycology,
Saint-Petersburg
Russian FederationL. V. Filippova
North-Western State Medical University named after I. I. Mechnikov
Email: fake@neicon.ru
PhD, Senior Researcher of Immunology and Allergology Kashkin Research Institute of Medical Mycology,
Saint-Petersburg
Russian FederationN. V. Vasileva
North-Western State Medical University named after I. I. Mechnikov
Email: fake@neicon.ru
PhD, director of Kashkin Research Institute of Medical Mycology,
Saint-Petersburg
Russian FederationN. N. Klimko
North-Western State Medical University named after I. I. Mechnikov
Email: fake@neicon.ru
PhD, Head of Department of Clinical Mycology, Allergology and Immunology,
Saint-Petersburg
Russian FederationReferences
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- Agarwal R. A., Chakrabarti A., Shah D., Gupta D., Meis J. F., Guleria R., Moss R., Denning D. W. For the ABPA complicating asthma ISHAM working group 2013. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clinical & Experimental Allergy. 2013; 43, 850–873.
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