FLOW CYTOMETRIC ANALYSIS EXPRESSION MARKERS OF ACTIVATION ON CD4 T-LYMPHOCYTES AT RHEUMATOID ARTHRITIS

Cover Page

Cite item

Abstract

In research, it is studied coexpression CD69 and HLA-DR on sinovial T-lymphocytes at rheumatoid arthritis. The received results allow to assume, that in sinovial fluid there is a constant activation of T-cell that leads expression a marker CD69 on a surface chronically it stimulates lymphocytes only at the location the inflammation.

About the authors

E. G. Kostolomova

«Tyumen filial of the Institute Clinical Immunology»;
FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: lenakost@mail.ru

PhD (Biology), the assistant to faculty of pathological physiology,

Tyumen

Russian Federation

U. G. Suhovej

«Tyumen filial of the Institute Clinical Immunology»

Email: fake@neicon.ru

MD (Medicine), Professor, Director,

Tyumen

Russian Federation

I. G. Unger

«Tyumen filial of the Institute Clinical Immunology»

Email: fake@neicon.ru

PhD (Medicine), leading research associate,

Tyumen

Russian Federation

T. V. Akuneeva

«Tyumen filial of the Institute Clinical Immunology»

Email: fake@neicon.ru

senior research associate,

Tyumen

Russian Federation

O. A. Krivonosova

FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

student,

Tyumen

Russian Federation

T. V. Zenkova

FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

student,

 Tyumen

Russian Federation

O. V. Makeeva

FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

student,

 Tyumen

Russian Federation

O. J. Shvets

FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

student,

 Tyumen

Russian Federation

References

  1. Veale D. J. Cellular and molecular perspectives in rheumatoid arthritis / D. J. Veale, C. Orr, U. Fearon // Semin Immunopathol. – 2017. doi: 10.1007/s00281-017-0633-1.
  2. Moore T. L. Immune Complexes in Juvenile Idiopathic Arthritis / T. L. Moore // Front Immunol. – 2016. – Vol.7. – P. 177. doi: 10.3389/fimmu.2016.00177.
  3. Shipkova M., Wieland E. Surface markers of lymphocyte activation and markers of cell proliferation. Clin.Chim. Acta., 2012, vol. 413, no. 17–18, pp. 1338–1349.
  4. Wieland E., Shipkova M. Lymphocyte surface molecules as immune activation biomarkers // Clin Biochem. – 2016. – Vol.49(4–5). – P. 347–354.
  5. Чередеев Н. А., Горлина Н. К., Козлов И. Г. CDмар ке ры в практике клинико-диагностических лабораторий // Клиническая лабораторная диагностика. – 1999, № 6. С. 24–31.
  6. Yamada H., Nakashima Y., Okazaki K., Mawatari T., Fukushi J., Oyamada A., Fujimura K., Iwamoto Y., Yoshikai Y. Preferential Accumulation of Activated Th1 Cells Not Only in Rheumatoid Arthritis But Also in Osteoarthritis Joints // The Journal of Rheumatology. – 2011. – Vol. 38, № 8. – P. 1569–1575.
  7. Testi R., Pulcinelli F. M., Cifone M. G., Trotta R., Torelli G., Demaria R., Frati L., Santoni A. Signaling in T lymphocytes: a possible accessory pathway initiated at the CD69 receptor. J. Immunol. Res. 1992, 4, 111–117.

Copyright (c) 2019 Kostolomova E.G., Suhovej U.G., Unger I.G., Akuneeva T.V., Krivonosova O.A., Zenkova T.V., Makeeva O.V., Shvets O.J.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies