THE ANALYSIS OF PERIPHERAL BLOOD CYTOKINES IN WOMEN WITH RECURRENT SPONTANEOUS ABORTION

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Abstract

The level of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IFNγ, TNFα, GM-CSF in the peripheral blood of women with recurrent spontaneous abortion and uncomplicated pregnancy was investigated at 5–12 weeks of gestation. It was established, that the serum level of IL-1β, IL-22, IL-23 and IL-27 in women with habitual abortion increased, and the tendency to the elevation of serum level of IL-10 и IL-13 was seen.

About the authors

N. V. Kroshkina

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia

Email: fake@neicon.ru

PhD, researcher of the laboratory of clinical immunology,

Ivanovo

Russian Federation

A. V. Kust

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia

Author for correspondence.
Email: niimid.immune@mail.ru

postgraduate Student of the laboratory of clinical immunology,

Ivanovo

Russian Federation

E. V. Kozelkova

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia

Email: fake@neicon.ru

postgraduate Student of the Department of Obstetrics and Gynecology, Neonatology, Anesthesiology and Reanimatology,

Ivanovo

Russian Federation

References

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  2. Southcombe J., Tannetta D., Redman C., Sargent I. The immunomodulatory role of syncytiotrophoblast microvesicles. PLos One. 2011, 6(5): e20245.
  3. Батрак Н. В., Малышкина А. И., Сотникова Н. Ю., Крошкина Н. В. Урогенитальная инфекция как фактор риска рецидивирующих потерь беременности. Российский иммунологический журнал. 2015, 9(18); 1(1), 19–20. [Batrak N. V., Malyshkina A. V., Sotnikova N. Yu., Kroshkina N. V. Urogenital infection as risk factor of recurrent miscarriage. Russian Journal of Immunology. 2015, 9(18); 1(1), 19–20].
  4. Caprioli F., Sarra M., Caruso R., Stolfi C., Fina D., Sica G., MacDonald T. T., Pallone F., Monteleone G. Autocrine regulation of IL-21 production in human T lymphocytes. J Immunol. 2008, 180(3), 1800–1807.
  5. Zotos D., Coquet J. M., Zhang Y., Light A., D’Costa K., Kallies A., Corcoran L. M., Godfrey D. I., Toellner K. M., Smyth M. J., Nutt S. L., Tarlinton D. M. IL-21 regulates germinal center B cell diff erentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med. 2010, 207(2), 365–378.

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Copyright (c) 2019 Kroshkina N.V., Kust A.V., Kozelkova E.V.

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