Email this article CYTOKINE PROFILE OF NEWBORN CHILDREN WITH GENERALIZED HERPETIC INFECTION
- Authors: Levkovich M.A.1, Kravchenko L.V.1, Levkovich A.Y.1,2, Pyatikova M.V.1
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Affiliations:
- Rostov State Medical University, Ministry of Health of Russia
- Regional Clinical Hospital № 2
- Issue: Vol 22, No 2-1 (2019)
- Pages: 368-370
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/151
- DOI: https://doi.org/10.31857/S102872210006630-8
- ID: 151
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Abstract
New data confirming the role of immune system disorders in the pathogenesis of generalized herpes infection are presented. It has been established that in newborns the development of generalized herpes virus infection is associated with impaired cytokine balance, with a tendency to T2 directional type of immune response, insufficiency of IFNα and IFNγ production.
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About the authors
M. A. Levkovich
Rostov State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: xlma@mail.ru
Doctor of Medical Sciences, Associate Professor, Leading Researcher of the Department of Biomedical Problems in Obstetrics, Gynecology and Pediatrics,
Rostov-on-Don
Russian FederationL. V. Kravchenko
Rostov State Medical University, Ministry of Health of Russia
Email: fake@neicon.ru
doctor of medical sciences, associate professor, leading researcher of the pediatric department,
Rostov-on-Don
Russian FederationA. Yu. Levkovich
Rostov State Medical University, Ministry of Health of Russia;Regional Clinical Hospital № 2
Email: fake@neicon.ru
Candidate of Medical Sciences, head. Department of Newborns,
Rostov-on-Don
Russian FederationM. V. Pyatikova
Rostov State Medical University, Ministry of Health of Russia
Email: fake@neicon.ru
pediatrician of the department of young children,
Rostov-on-Don
Russian FederationReferences
- Purewal R., Costello L., Garlapat S., Mitra S., Mitchell M., Moffett K. S. Congenital Herpes Simplex Virus in the Newborn: A Diagnostic Dilemma. Journal of the Pediatric Infectious Diseases Society. 2016, 5(3), e21–e23
- Gantt S. and Muller W. J. The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention. Clin Dev Immunol. 2013,1–16.
- Кравченко Л. В., Левкович М. А. Механизмы иммуносупрессии при частых острых респираторновирусных инфекциях у детей, перенесших цитомегаловирусную инфекцию в периоде новорожденности. ВИЧ-инфекция и иммуносупрессии. 2017, 9(3), 34–38.
- Левкович М. А., Афонин А. А., Кравченко Л. В., Левкович А. Ю., Демидова М. В., Заурова Л. М. Показатели иммунного статуса и функциональной активности лимфоцитов у новорожденных детей с герпесвирусной инфекцией. Российский аллергологический журнал. 2013, 2–2, 174–175.
- Кравченко Л. В., Левкович М. А., Пятикова М. В. Роль полиморфизма гена интерферона γ и интерферонопродукции в патогенезе инфекции, вызванной вирусом герпеса 6 типа у детей раннего возраста. Клиническая лабораторная диагностика. 2018, 63(6), 357–361.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).