IMMUNOREHABILITATION DRUGS OF MAGNESIUM IN ACUTE DESTRUCTIVE PANCREATITIS IN THE EXPERIMENT
- Authors: Loktionova A.V.1, Bystrova N.A.1, Loktionov A.L.1
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Affiliations:
- Kursk State Medical University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 380-382
- Section: ORIGINAL ARTICLES
- Submitted: 04.05.2020
- Accepted: 04.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/155
- DOI: https://doi.org/10.31857/S102872210006634-2
- ID: 155
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Abstract
Studies were conducted on 108 healthy Wistar rats weighing 150‒200 g. Acute destructive pancreatitis (ADP) was modeled on the eve of the removal of animals from the experiment ligation of the ducts of the pancreas with subsequent stimulation by neostigmine. Investigated the influence of preparations of magnesium (Magne B6, Magnelis and Panangin) in the context of ADP on immunological reactivity. In ADP established reduction of phagocytosis, increased oxygen-dependent metabolism of circulating blood granulocytes, suppression of the formation of humoral and cellular forms of immune response. The most eff ective in correcting the parameters of innate and adoptive immunity was Magne B6, then, according to the degree of decrease in the effectiveness of Magnelis and Panangin.
About the authors
A. V. Loktionova
Kursk State Medical University
Author for correspondence.
Email: ana-loc@yandex.ru
correspondence post-graduate student, Department of Pediatrics,
Kursk
Russian FederationN. A. Bystrova
Kursk State Medical University
Email: fake@neicon.ru
Doctor of Medicine, Professor, Department of Biochemistry,
Kursk
Russian FederationA. L. Loktionov
Kursk State Medical University
Email: fake@neicon.ru
Doctor of Medicine, Professor of the Department of surgical diseases № 2,
Kursk
Russian FederationReferences
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