Email this article sIgE TO BACTERIAL ALLERGENES IN PATIENTS WITH CHRONIC INFLAMMATORY PULMONARY DISEASES
- Authors: Mazurina S.A.1, Konishcheva A.Y.1, Ospelnikova T.P.1, Gervazieva V.B.1
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Affiliations:
- Mechnikov Research Institute for Vaccines and Sera
- Issue: Vol 22, No 2-1 (2019)
- Pages: 388-390
- Section: ORIGINAL ARTICLES
- Submitted: 04.05.2020
- Accepted: 04.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/158
- DOI: https://doi.org/10.31857/S102872210006906-1
- ID: 158
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Abstract
Infections colonization colonization of the bronchopulmonary biotope is considered as one of the likely factors for maintaining the inflammatory process with a predominance of the Th2 immune response in patients with chronic diseases of the lung airway. The aim of the study was to assess the IgE immune response to the main microorganisms lung airway. Patients and methods: In the blood serum of 69 patients with BA, COPD and АСОS, the content of total IgE and sIgE for bacterial allergens, sIgA level in saliva was determined by ELISA. Results. In patients with АСОS, a wider spectrum of sIgE to bacterial allergens is presented, against the background of reduced levels of sIgA in saliva, in comparison with patients with asthma and COPD. This may indicate the involvement of innate immunity due to the IgE system in relation to anti-infective protection in patients with АСОS.
Keywords
About the authors
S. A. Mazurina
Mechnikov Research Institute for Vaccines and Sera
Author for correspondence.
Email: svetulyok@list.ru
Ph.D., Leading Researcher at the lab. allergodiagnostic,
Russian Federation
A. Yu. Konishcheva
Mechnikov Research Institute for Vaccines and Sera
Email: fake@neicon.ru
Ph.D., Leading Researcher at the lab. allergodiagnostic,
Russian Federation
T. P. Ospelnikova
Mechnikov Research Institute for Vaccines and Sera
Email: fake@neicon.ru
Ph.D., Head. of the lab. Interferons,
Russian Federation
V. B. Gervazieva
Mechnikov Research Institute for Vaccines and Sera
Email: fake@neicon.ru
Prof., MD, Head of the Department of Allergology,
Russian Federation
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).