Email this article STUDY OF ANTIBODIES TO β2-GLYKOPROTEIN-I AND DOMAIN I IN WOMEN WITH RECURRENT PREGNANCY LOSS
- Authors: Menzhinskaya I.V.1, Van’ko L.V.1
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Affiliations:
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 403-405
- Section: ORIGINAL ARTICLES
- Submitted: 04.05.2020
- Accepted: 04.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/163
- DOI: https://doi.org/10.31857/S102872210006911-7
- ID: 163
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Abstract
Antibodies to β2-GP-I are an independent risk factor for recurrent pregnancy loss (RPL).A good agreement between the results of ELISA and chemiluminescent immunoassay was shown in the determination of medium and high anti-β2-GP-I antibody concentrations. Antibodies to domain I were often found in the patients seropositive for anti-β2-GP-I antibodies. Detection of antibodies to domain I has important clinical significance for the stratification of patients by risk of thrombosis and obstetric complications.
About the authors
I. V. Menzhinskaya
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation
Author for correspondence.
Email: i_menzinskaya@oparina4.ru
PhD in Medical sciences, Senior Researcher of the Laboratory of Clinical Immunology,
Moscow
Russian FederationL. V. Van’ko
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation
Email: fake@neicon.ru
д. м. н., профессор, ведущий научный сотрудник лаборатории клинической иммунологии,
Москва
Russian FederationReferences
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