IL-10 PRODUCTION BY PLACENTAL MACROPHAGES IN DEPENDENCE TO IL-10 POLYMORPHISM

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Abstract

IL-10 polymorpism А-1082G but not А-592C is the significant factor in the regulationof immune ractions at the placental level and it can be used as one of the predictors of the intrauterine growth retardation development.

About the authors

P. L. Mileyeva

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of Russia

Email: fake@neicon.ru

obstetrician-gynecologist of the obstetric physiological department of the inpatient department of the clinic,

Ivanovo 

Russian Federation

D. N. Voronin

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of Russia

Author for correspondence.
Email: fake@neicon.ru

PhD, senior researcher of the laboratory of clinical immunology,

Ivanovo 

Russian Federation

Y. L. Boyko

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of Russia

Email: fake@neicon.ru

MD, senior researcher, Department of Obstetrics and Gynecology,

Ivanovo 

Russian Federation

I. N. Fetisova

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of Russia

Email: fake@neicon.ru

MD, Leading Researcher of the Laboratory of Clinical Biochemistry and Genetics, genetic doctor,

Ivanovo 

Russian Federation

References

  1. Song L., Zhong M. Association between Interleukin-10 gene polymorphisms and risk of early-onset preeclampsia. Int J Clin Exp Pathol. 2015, 8 (9), 11659–11664.
  2. Liu Q. Y., Gao F. Y., Liu X. R., Li J., Ji M., Dong J., Wang X. T. Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia. Genet Mol Res. 2015, 14 (4), 19323–19328.
  3. Sowmya S., K. Sri. Manjari, Ramaiah A., Sunitha Т., Nallari Р., Jyothy А., Venkateshwari А. Interleukin 10 gene promoter polymorphisms in women with earlyonset preeclampsia. Clin Exp Immunol. 2014, 178 (2), 334–341.

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Copyright (c) 2019 Mileyeva P.L., Voronin D.N., Boyko Y.L., Fetisova I.N.

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